M
Matthew J. Smalley
Researcher at Cardiff University
Publications - 94
Citations - 6957
Matthew J. Smalley is an academic researcher from Cardiff University. The author has contributed to research in topics: Stem cell & Progenitor cell. The author has an hindex of 42, co-authored 89 publications receiving 6306 citations. Previous affiliations of Matthew J. Smalley include The Breast Cancer Research Foundation & Hammersmith Hospital.
Papers
More filters
Journal ArticleDOI
BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells
Gemma Molyneux,Felipe C. Geyer,Fiona-Ann Magnay,Afshan McCarthy,Howard Kendrick,Rachael Natrajan,Alan Mackay,Anita Grigoriadis,Andrew Tutt,Alan Ashworth,Jorge S. Reis-Filho,Matthew J. Smalley +11 more
TL;DR: It is demonstrated that deleting Brca1 in mouse mammary epithelial luminal progenitors produces tumors that phenocopy human BRCA1 breast cancers and that when target cells for transformation have the potential for phenotypic plasticity, tumor phenotypes may not directly reflect histogenesis.
Journal ArticleDOI
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.
Suzanne A. Eccles,Eric O. Aboagye,Simak Ali,Annie S. Anderson,Jo Armes,Fedor Berditchevski,Jeremy P. Blaydes,Keith Brennan,Nicola J. Brown,Helen E. Bryant,Nigel J Bundred,Joy Burchell,Anna Campbell,Jason S. Carroll,Robert Clarke,Charlotte E. Coles,Gary Cook,Angela Cox,Nicola J. Curtin,Lodewijk V. Dekker,Isabel dos Santos Silva,Stephen W. Duffy,Douglas F. Easton,Diana Eccles,Dylan R. Edwards,Joanne Edwards,D. G. R. Evans,Deborah Fenlon,James M. Flanagan,Claire Foster,William M. Gallagher,Montserrat Garcia-Closas,Julia Margaret Wendy Gee,Andy J. Gescher,Vicky Goh,Ashley M. Groves,Amanda J. Harvey,Michelle Harvie,Bryan T. Hennessy,Stephen Edward Hiscox,Ingunn Holen,Sacha J Howell,Anthony Howell,Gill Hubbard,Nicholas J. Hulbert-Williams,Myra S. Hunter,Bharat Jasani,Louise J. Jones,Timothy J. Key,Cliona C. Kirwan,Anthony Kong,Ian Kunkler,Simon P. Langdon,Martin O. Leach,David J. Mann,John Marshall,Lesley Ann Martin,Stewart G. Martin,Jennifer E. Macdougall,David Miles,William R. Miller,Joanna R. Morris,Sue Moss,Paul B. Mullan,Rachel Natrajan,James P B O'Connor,Rosemary O'Connor,Carlo Palmieri,Paul D.P. Pharoah,Emad A. Rakha,Elizabeth Reed,Simon P. Robinson,Erik Sahai,John M. Saxton,Peter Schmid,Matthew J. Smalley,Valerie Speirs,Robert Stein,John Stingl,Charles H. Streuli,Andrew Tutt,Galina Velikova,Rosemary A. Walker,Christine J. Watson,Kaye J. Williams,Leonie S. Young,Alastair M. Thompson +86 more
TL;DR: With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.
Journal ArticleDOI
Stem cells and breast cancer: A field in transit.
Matthew J. Smalley,Alan Ashworth +1 more
TL;DR: What evidence is there that an adult mammary epithelial stem cell exists, what is its possible identity and what opportunities might the identification of such a cell present for the development of novel therapeutic and prophylactic strategies for treating breast cancer?
Journal ArticleDOI
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells
TL;DR: Differential staining of mammary epithelial cells for CD24 can be used to simultaneously isolate pure populations of non-epithelial, myoepithel/basal and luminal epithelialcells, which is key for understanding mammaries epithelial stem cells in normal tissue biology and carcinogenesis.
Journal ArticleDOI
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.
Katherine E Sleeman,Howard Kendrick,David J. Robertson,Clare M. Isacke,Alan Ashworth,Matthew J. Smalley +5 more
TL;DR: Flow cytometry is used to prospectively isolate mouse mammary ER-expressing epithelial cells and shown, using analysis of gene expression patterns and cell type–specific markers, that they form a distinct luminal epithelial cell subpopulation that expresses not only the ER but also the progesterone and prolactin receptors.