J
Jen-Chieh Hsieh
Researcher at Tamkang University
Publications - 48
Citations - 1079
Jen-Chieh Hsieh is an academic researcher from Tamkang University. The author has contributed to research in topics: Catalysis & Aryne. The author has an hindex of 18, co-authored 47 publications receiving 949 citations. Previous affiliations of Jen-Chieh Hsieh include University of Texas Southwestern Medical Center & Vienna University of Technology.
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Journal ArticleDOI
Structure/Activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response
Jianming Lu,Zhiqiang Ma,Jen-Chieh Hsieh,Chih Wei Fan,Baozhi Chen,Jamie Longgood,Noelle S. Williams,James F. Amatruda,Lawrence G. Lum,Chuo Chen +9 more
TL;DR: A novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex are reported.
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Novel Syntheses of Fluorenones via Nitrile-Directed Palladium-Catalyzed C–H and Dual C–H Bond Activation
TL;DR: Novel procedures for the [Pd]/[Ag]/TFA system catalyzed cascade reactions of nitrile directed remote C-H and dual C- H bond activation with insertion of nitRIle were developed, which afforded variously polysubstituted fluorenones in moderate to good yields with tolerance of a wide variety of substrates.
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O-Dihaloarenes as aryne precursors for nickel-catalyzed [2 + 2 + 2] cycloaddition with alkynes and nitriles
Jen-Chieh Hsieh,Chien-Hong Cheng +1 more
TL;DR: Dihaloarenes acting as aryne precursors react with acetylenes and nitriles catalyzed by the NiBr(2)(dppe)/dppe/Zn system to give substituted naphthalene, phenanthridine or triphenylene derivatives depending on the reaction conditions in moderate to excellent yields with good tolerance of functional groups.
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Nickel-catalyzed intermolecular insertion of aryl iodides to nitriles: a novel method to synthesize arylketones.
TL;DR: A novel procedure for the NiCl(2)(DME)/dppp/Zn system catalyzed intermolecular insertion of aryl iodides to nitriles was developed, which afforded variously substituted aryalketone derivatives in moderate to good yields with tolerance of a wide variety of functional groups.
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Nickel-catalyzed highly chemoselective cocyclotrimerization of arynes with allenes: a novel method for 10-methylene-9,10-dihydrophenanthrenes.
TL;DR: The NiBr(2)(dppe)-Zn system effectively catalyzes the [2+2+ 2] cocyclotrimerization of arynes with allenes, leading to 10-methylene-9,10-dihydrophenanthrenes in moderate to good yields as discussed by the authors.