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Chih Wei Fan
Researcher at University of Texas Southwestern Medical Center
Publications - 7
Citations - 1667
Chih Wei Fan is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Signal transduction & Wnt signaling pathway. The author has an hindex of 6, co-authored 7 publications receiving 1537 citations. Previous affiliations of Chih Wei Fan include University of Texas at Dallas.
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Journal ArticleDOI
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Baozhi Chen,Michael E. Dodge,Wei Tang,Jianming Lu,Zhiqiang Ma,Chih Wei Fan,Shuguang Wei,Wayne Hao,Jessica A. Kilgore,Noelle S. Williams,Michael G. Roth,James F. Amatruda,Chuo Chen,Lawrence G. Lum +13 more
TL;DR: Two novel classes of small molecules are discovered that disrupt Wnt pathway responses and contribute to Wnt-independent signal transduction pathways and thus could be broadly exploited for chemical genetics and therapeutic goals.
Journal ArticleDOI
Structure/Activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response
Jianming Lu,Zhiqiang Ma,Jen-Chieh Hsieh,Chih Wei Fan,Baozhi Chen,Jamie Longgood,Noelle S. Williams,James F. Amatruda,Lawrence G. Lum,Chuo Chen +9 more
TL;DR: A novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex are reported.
Journal ArticleDOI
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.
Leni S. Jacob,Xiaofeng Wu,Michael E. Dodge,Chih Wei Fan,Ozlem Kulak,Baozhi Chen,Wei Tang,Baolin Wang,James F. Amatruda,Lawrence G. Lum +9 more
TL;DR: It is found that Stk11 loss resulted in disassembly of the primary cilium, a cellular organizing center for Hh pathway components, thus dampening Hh signaling, and this approach provides a platform to support the development of targeted therapeutic strategies.
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Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor
Xiaofeng Wu,Li Shu Zhang,Jason E. Toombs,Yi Chun Kuo,John Tyler Piazza,Rubina Tuladhar,Quinn Barrett,Chih Wei Fan,Xuewu Zhang,Loren D. Walensky,Marcel Kool,Steven Y. Cheng,Rolf A. Brekken,Joseph T. Opferman,Douglas R. Green,Tudor Moldoveanu,Lawrence G. Lum +16 more
TL;DR: A chemical strategy for countering drug resistance in GLI-associated tumours is delineated and unanticipated functions for BCL-2 proteins as transcriptional regulators are revealed ascriptional regulators of a prosurvival and growth program.
Journal ArticleDOI
The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation
Chih Wei Fan,Baozhi Chen,Irene Franco,Jianming Lu,Heping Shi,Shuguang Wei,Chang-Guang Wang,Xiaofeng Wu,Wei Tang,Michael G. Roth,Noelle S. Williams,Emilio Hirsch,Chuo Chen,Lawrence G. Lum +13 more
TL;DR: It is demonstrated that Smo supplied with a synthetic agonist or activated with oncogenic mutations can signal without ciliary accumulation, and that cells with compromised ciliary Smo trafficking due to loss of the phosphatidylinositol-4-phosphate 3-kinase (PI3K)-C2α retain transcriptional response to an exogenously supplied Smo agonist.