J
Jennifer A. Flegg
Researcher at University of Melbourne
Publications - 75
Citations - 4037
Jennifer A. Flegg is an academic researcher from University of Melbourne. The author has contributed to research in topics: Malaria & Medicine. The author has an hindex of 24, co-authored 60 publications receiving 3445 citations. Previous affiliations of Jennifer A. Flegg include Monash University & University of Oxford.
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Journal ArticleDOI
Defining the In Vivo Phenotype of Artemisinin-Resistant Falciparum Malaria: A Modelling Approach
Lisa J. White,Jennifer A. Flegg,Aung Pyae Phyo,Ja Hser Wiladpai-ngern,D. Bethell,Christopher V. Plowe,Tim J. C. Anderson,Standwell Nkhoma,Shalini Nair,Rupam Tripura,Kasia Stepniewska,Wirichada Pan-Ngum,Kamolrat Silamut,Ben S. Cooper,Yoel Lubell,Elizabeth A. Ashley,Chea Nguon,François Nosten,Nicholas J. White,Arjen M. Dondorp +19 more
TL;DR: Characterisation of overlapping distributions of parasite half-lives provides quantitative insight into the relationship between parasite clearance and artemisinin resistance, as well as the predictive value of the 10% cut-off in 'day-3' parasitaemia.
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Trends in Antimalarial Drug Use in Africa
Jennifer A. Flegg,Charlotte Jessica Eland Metcalf,Myriam Gharbi,Meera Venkatesan,Tanya Shewchuk,Carol Hopkins Sibley,Philippe J Guerin +6 more
TL;DR: If artemisinin resistance spreads to, or emerges in, Africa this methodology will be a valuable tool to estimate actual drug use and its impact on changes in drug efficacy.
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High-Throughput Analysis of Antimalarial Susceptibility Data by the WorldWide Antimalarial Resistance Network (WWARN) In Vitro Analysis and Reporting Tool
Charles J. Woodrow,Charles J. Woodrow,Sabina Dahlström,Richard Cooksey,Jennifer A. Flegg,Hervé Le Nagard,Claribel Murillo,Didier Menard,François Nosten,Kanlaya Sriprawat,Lise Musset,Neils B. Quashie,Pharath Lim,Rick M. Fairhurst,Sam L. Nsobya,Véronique Sinou,Harald Noedl,Bruno Pradines,Jacob D. Johnson,Philippe J Guerin,Carol Hopkins Sibley,Carol Hopkins Sibley,Jacques Le Bras,Jacques Le Bras +23 more
TL;DR: A Web-based, high-throughput in vitro analysis and reporting tool (IVART) generating inhibitory constants for large data sets, showing that maximal drug inhibition was higher for artemisinins than for other drugs, particularly in ELISA (enzyme-linked immunosorbent assay)-based assays.
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Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000–2011
Myriam Gharbi,Jennifer A. Flegg,Véronique Hubert,Eric Kendjo,Jessica Metcalf,Lionel Bertaux,Philippe J Guerin,Jacques Le Bras +7 more
TL;DR: An increase in CQ susceptibility following official withdrawal of the drug was observed in travellers returning from West and Central African countries, and they correlated to the decrease of thedrug pressure.
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Wound healing angiogenesis: The clinical implications of a simple mathematical model
TL;DR: In this article, a deterministic mathematical model, formulated as a system of partial differential equations, was developed for wound angiogenesis and wound-bed angiotensinosis.