J
Jennifer Eve Fenner
Researcher at Monash Institute of Medical Research
Publications - 4
Citations - 1566
Jennifer Eve Fenner is an academic researcher from Monash Institute of Medical Research. The author has contributed to research in topics: Suppressor of cytokine signaling 1 & IRF8. The author has an hindex of 3, co-authored 3 publications receiving 1495 citations. Previous affiliations of Jennifer Eve Fenner include Monash Medical Centre.
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Journal ArticleDOI
SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine
Warren S. Alexander,Robyn Starr,Robyn Starr,Jennifer Eve Fenner,Clare L. Scott,Clare L. Scott,Emanuela Handman,Naomi S. Sprigg,Naomi S. Sprigg,Jason Corbin,Jason Corbin,Ann L Cornish,Ann L Cornish,Rima Darwiche,Catherine M Owczarek,Thomas W.H. Kay,Nicos A. Nicola,Nicos A. Nicola,Paul J. Hertzog,Donald Metcalf,Donald Metcalf,Douglas J. Hilton,Douglas J. Hilton +22 more
TL;DR: It is indicated that SOCS1 is a key modulator of IFNgamma action, allowing the protective effects of this cytokine to occur without the risk of associated pathological responses.
Journal ArticleDOI
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
Ashley Mansell,Rosealee Anne Smith,Sarah L. Doyle,Pearl Gray,Jennifer Eve Fenner,Peter J Crack,Sandra E. Nicholson,Douglas J. Hilton,Luke A. J. O'Neill,Paul J. Hertzog +9 more
TL;DR: The data identify a target of SOCS-1 that regulates TLR signaling via a mechanism distinct from an autocrine cytokine response and is a rapid and selective means of limiting primary innate immune response.
Journal ArticleDOI
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
Jennifer Eve Fenner,Robyn Starr,Ann L. Cornish,Ann L. Cornish,Jian-Guo Zhang,Donald Metcalf,Robert D. Schreiber,Kathleen C. F. Sheehan,Douglas J. Hilton,Warren S. Alexander,Paul J. Hertzog +10 more
TL;DR: SOCS1 is an important in vivo inhibitor of type I interferon signaling and contributes to balancing its beneficial antiviral versus detrimental proinflammatory effects on innate immunity.
Journal ArticleDOI
N-chlorotaurine is highly active against respiratory viruses including SARS-CoV-2 (COVID-19) in vitro
Michaela Lackner,Annika Rössler,André Volland,Marlena Stadtmüller,Brigitte Müllauer,Zoltán Bánki,Johannes Ströhle,Angela Luttick,Jennifer Eve Fenner,Bettina Sarg,Leopold Kremser,Paul Tone,Heribert Stoiber,Dorothee von Laer,Thorsten Wolff,Carsten Schwarz,Markus Nagl +16 more
TL;DR: The activity of NCT is demonstrated against viruses causing acute respiratory tract infections, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza viruses, and respiratory syncytial virus (RSV).