J
Jennifer L. Payne
Researcher at Johns Hopkins University School of Medicine
Publications - 112
Citations - 4746
Jennifer L. Payne is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Postpartum depression & Pregnancy. The author has an hindex of 31, co-authored 99 publications receiving 3973 citations. Previous affiliations of Jennifer L. Payne include Johns Hopkins University & National Institutes of Health.
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Journal ArticleDOI
Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression.
Husseini K. Manji,Jorge A. Quiroz,Jonathan R. Sporn,Jennifer L. Payne,Kirk D. Denicoff,Neil A. Gray,Carlos A. Zarate,Dennis S. Charney +7 more
TL;DR: Preclinical studies have shown that critical molecules in neurotrophic signaling cascades are long-term targets for antidepressant agents and antidepressant potentiating modalities, suggesting that effective treatments provide both trophic and neurochemical support, which serves to enhance and maintain normal synaptic connectivity.
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An open-label trial of riluzole in patients with treatment-resistant major depression.
Carlos A. Zarate,Jennifer L. Payne,Jorge A. Quiroz,Jonathan R. Sporn,Kirk K. Denicoff,David A. Luckenbaugh,Dennis S. Charney,Husseini K. Manji +7 more
TL;DR: Results indicate that riluzole may have antidepressant properties in some patients, and these results indicate that the drug may be able to overcome treatment resistance in patients with recurrent major depression.
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Pramipexole for bipolar II depression: a placebo-controlled proof of concept study.
Carlos A. Zarate,Jennifer L. Payne,Jaskaran Singh,Jorge A. Quiroz,David A. Luckenbaugh,Kirk D. Denicoff,Dennis S. Charney,Husseini K. Manji +7 more
TL;DR: The dopamine agonist pramipexole was found to have significant antidepressant effects in patients with bipolar II depression and showed a significant treatment effect for total Montgomery-Asberg Depression Rating Scale scores.
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Major depressive disorder in DSM-5: Implications for clinical practice and research of changes from DSM-IV
TL;DR: The replacement of an operationalized bereavement exclusion with a call for clinical judgment in distinguishing normal reactions to significant loss from a disorder in need of clinical attention makes the diagnosis less objective and complicates investigations of the relationship between adversity and depression.
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Clinical phenotypes of perinatal depression and time of symptom onset: analysis of data from an international consortium
Karen T. Putnam,Marsha A. Wilcox,Emma Robertson-Blackmore,Katherine M. Sharkey,Veerle Bergink,Trine Munk-Olsen,Kristina M. Deligiannidis,Jennifer L. Payne,Margaret Altemus,Jeffrey Newport,Gisèle Apter,Emmanuel Devouche,Alexander Viktorin,Patrik K. E. Magnusson,Brenda W.J.H. Penninx,Anne Buist,Justin L C Bilszta,Michael W. O'Hara,Scott Stuart,Rebecca L. Brock,Sabine J. Roza,Henning Tiemeier,Constance Guille,C. Neill Epperson,Deborah R. Kim,Peter Schmidt,Pedro E. Martinez,Arianna Di Florio,Katherine L. Wisner,Zachary N. Stowe,Ian Jones,Patrick F. Sullivan,Patrick F. Sullivan,David R. Rubinow,Kevin Wildenhaus,Samantha Meltzer-Brody +35 more
TL;DR: The findings show that there might be different types and severity of perinatal depression with varying time of onset throughout pregnancy and post partum, and support the need for tailored treatments that improve outcomes for women with perInatal depression.