Jennifer Noteboom

TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.

TL;DR: The PCA3 assay is insensitive to pre-analytical factors, performs well analytically and correctly classifies a high percent of subjects with known prostate cancer status across research sites.

TL;DR: PSA levels are undetectable in most men who do not have recurrence of disease after radical prostatectomy, and PSA assays with enhanced sensitivity can detect recurrent prostate cancer with significant lead time over conventional assays.

TL;DR: The major source of urinary PSA following total prostatectomy is the urethra itself rather than residual prostate tissue, which appears to have limited value in monitoring patients after radical prostatectom.

TL;DR: Serum percent fPSA in men after RP with persistent prostate cancer encompasses a wide range of values with no clear stratifying factor or factors, and further serial studies in patients with progressive metastatic disease may be important in determining the mechanism(s) for lower percent PSA in men with newly diagnosed prostate cancer.