Jennifer W. Anderson

TL;DR: Despite good efficacy as an oral agent in murine models, the low oral absorption of this class may limit the use of MK-991 to parenteral therapy.

TL;DR: PfPKG has biochemical and pharmacological properties that are similar to previously characterized apicomplexan PKG enzymes, including substrate preference and inhibition of Pf(Tg)PKG kinase activity by Compound 1 are similarTo enable a more thorough characterization of PfPKG, a synthetic cDNA incorporating T. gondii codon preference was expressed.

TL;DR: A chemical genomics strategy based on 245 Staphylococcus aureus antisense RNA strains, each engineered for reduced expression of target genes essential for S. aUREus growth is described and its use in the discovery of new cell wall inhibitors is demonstrated.

TL;DR: EEF2 has been cloned and characterized from several sordarin-sensitive and -insensitive fungal species and it is shown that three amino acid residues within eEF2 account for the selectivity of this class of compounds.

TL;DR: Results indicate the presence of an essential histidine residue(s) at the M1Pase active site, as predicted for a histidine phosphatase.