M
Mohinder K. Sardana
Researcher at United States Military Academy
Publications - 25
Citations - 2104
Mohinder K. Sardana is an academic researcher from United States Military Academy. The author has contributed to research in topics: Peptide sequence & Protease. The author has an hindex of 15, co-authored 25 publications receiving 2042 citations. Previous affiliations of Mohinder K. Sardana include Merck & Co..
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Journal ArticleDOI
Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
Yueming Li,Min Xu,Ming-Tain Lai,Qian Huang,José L. Castro,Jillian DiMuzio-Mower,T. Harrison,C Lellis,Alan Nadin,Joseph G. Neduvelil,R B Register,Mohinder K. Sardana,Mark S. Shearman,Adrian L. Smith,Xiao Ping Shi,Kuo-Chang Yin,Jules A. Shafer,Stephen J. Gardell +17 more
TL;DR: In this paper, photoaffinity labeling of presenilin 1 and 2 (PS1 and PS2) was performed by potent gamma-secretase inhibitors that were designed to function as transition state analogue inhibitors directed to the active site of an aspartyl protease.
Journal ArticleDOI
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form
Youwei Yan,Ying Li,Sanjeev Munshi,V V Sardana,James L. Cole,Mohinder K. Sardana,C. Steinkuehler,Licia Tomei,R. De Francesco,Lawrence Kuo,Zhongguo Chen +10 more
TL;DR: Experimental support is provided for the proposal that binding of an NS4A‐mimicking peptide, which increases catalytic rates, is necessary but not sufficient for formation of a well‐ordered, compact and, hence, highly active protease molecule.
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Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target.
Anne Gurnett,Paul A. Liberator,Paula M. Dulski,Scott P. Salowe,Robert G. K. Donald,Jennifer W. Anderson,Judyann Wiltsie,Carmen Diaz,Georgiana Harris,Ben Chang,Sandra J. Darkin-Rattray,Bakela Nare,Tami Crumley,Penny Sue Blum,Andrew S. Misura,Tamas Tamas,Mohinder K. Sardana,Jeffrey Yuan,Tesfaye Biftu,Dennis M. Schmatz +19 more
TL;DR: A parasite signature sequence of nearly 300 amino acids that is not found in mammalian or DrosophilaPKG and which contains an additional, third cGMP-binding site is identified, which represents the first example of a protozoal PKG.
Journal ArticleDOI
Activity of purified hepatitis C virus protease NS3 on peptide substrates.
Christian Steinkühler,Andrea Urbani,Licia Tomei,Gabriella Biasiol,Mohinder K. Sardana,Elisabetta Bianchi,Antonello Pessi,R. De Francesco +7 more
TL;DR: Primary structure is an important determinant of the efficiency with which each site is cleaved during polyprotein processing, and slow cleavage of the NS4B-NS5A site in the absence of NS4A is due to low binding affinity of the enzyme for this site.
Journal ArticleDOI
The synthesis of a prodrug of doxorubicin designed to provide reduced systemic toxicity and greater target efficacy.
Victor M. Garsky,Patricia K. Lumma,Dong-Mei Feng,Jenny Wai,Ramjit Hg,Mohinder K. Sardana,Oliff Allen I,Raymond E. Jones,Deborah Defeo-Jones,Roger M. Freidinger +9 more
TL;DR: Both doxorubicin and Leu-Dox were ineffective in reducing circulating PSA and tumor burden at their maximum tolerated doses and were selected for further study to assess their ability to inhibit human prostate cancer cell growth and tumorigenesis.