J
Jens D. Mikkelsen
Researcher at Copenhagen University Hospital
Publications - 300
Citations - 13178
Jens D. Mikkelsen is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Hypothalamus & Receptor. The author has an hindex of 60, co-authored 293 publications receiving 12439 citations. Previous affiliations of Jens D. Mikkelsen include University of Copenhagen & Panum Institute.
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Distribution of glp-1 binding sites in the rat brain : evidence that exendin-4 is a ligand of brain glp-1 binding sites
TL;DR: The biochemical data support the idea that the central GLP‐1 receptor resembles the peripheral GLP-1 receptor, and the presence of GLp‐1 binding sites in the circumventricular organs suggests that these may be receptors which act as the target for both peripheral blood‐borne GLP1 and GLP•1 in the nervous system.
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Modulation of anxiety circuits by serotonergic systems.
TL;DR: The possibility that the regulation of anxiety states and anxiety-related behavior by serotonergic systems is dependent on a specific, topographically organized mesolimbocorticalserotonergic system that originates in the mid-rostrocaudal and caudal parts of the dorsal raphe nucleus is explored.
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Pituitary Adenylate Cyclase-Activating Peptide (PACAP) in the Retinohypothalamic Tract: A Potential Daytime Regulator of the Biological Clock
Jens Hannibal,Jian M. Ding,Dong Chen,Jan Fahrenkrug,Philip J. Larsen,Martha U. Gillette,Jens D. Mikkelsen,Jens D. Mikkelsen +7 more
TL;DR: A new signaling pathway by which the RHT may regulate circadian timing in the daytime as well, through a cAMP-dependent pathway, which could be blocked by a specific cAMP antagonist, Rp-cAMPS.
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Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters
Florent G. Revel,Michel Saboureau,Mireille Masson-Pévet,Paul Pévet,Jens D. Mikkelsen,Valérie Simonneaux +5 more
TL;DR: It is proposed that photoperiod, via melatonin, modulates KiSS-1 signaling to drive the reproductive axis, consistent with a role of Ki SS1/GPR54 in the seasonal control of reproduction.
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Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors.
David P.D. Woldbye,Philip J. Larsen,Jens D. Mikkelsen,Kristian Klemp,Torsten M. Madsen,Tom G. Bolwig +5 more
TL;DR: The present study is the first to demonstrate that NPY possesses anticonvulsant activity and suggests that agonists acting at Y5-like receptors may constitute a novel group of drugs in antiepileptic therapy.