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Anantha Shekhar
Researcher at Indiana University
Publications - 53
Citations - 5787
Anantha Shekhar is an academic researcher from Indiana University. The author has contributed to research in topics: Amygdala & Orexin. The author has an hindex of 30, co-authored 53 publications receiving 5326 citations. Previous affiliations of Anantha Shekhar include Memorial Hospital of South Bend.
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Journal ArticleDOI
Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia
Anantha Shekhar,William Z. Potter,Jeffrey Lightfoot,John Lienemann,Sanjay Dubé,Craig H. Mallinckrodt,Frank P. Bymaster,David L. McKinzie,Christian C. Felder +8 more
TL;DR: Results support further investigation of xanomeline as a novel approach to treating schizophrenia and show improvements most robustly in measures of verbal learning and short-term memory function.
Journal ArticleDOI
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.
M Ayalew,Helen Le-Niculescu,Daniel F. Levey,N Jain,B. Changala,S D Patel,Evan A. Winiger,A. Breier,Anantha Shekhar,Richard Amdur,Daniel L. Koller,John I. Nurnberger,Aiden Corvin,Mark A. Geyer,Ming T. Tsuang,Daniel R. Salomon,Nicholas J. Schork,Ayman H. Fanous,Michael Conlon O'Donovan,Alexander B. Niculescu,Alexander B. Niculescu +20 more
TL;DR: This work maps the genomic and biological landscape for schizophrenia, providing leads towards a better understanding of illness, diagnostics and therapeutics, and reveals the significant genetic overlap with other major psychiatric disorder domains, suggesting the need for improved nosology.
Journal ArticleDOI
A key role for orexin in panic anxiety
Philip L. Johnson,William A. Truitt,Stephanie D. Fitz,Pamela E Minick,Amy D. Dietrich,Sonal P. Sanghani,Lil Träskman-Bendz,Andrew Goddard,Lena Brundin,Anantha Shekhar +9 more
TL;DR: It is shown that activation of ORX-synthesizing neurons is necessary for developing a panic-prone state in the rat panic model, and that ORX antagonists constitute a potential new treatment strategy for panic disorder.
Journal ArticleDOI
Regulation of anxiety by GABAA receptors in the rat amygdala
S. K. Sanders,Anantha Shekhar +1 more
TL;DR: It is suggested that endogenous GABA acts tonically at GABAA receptors in the BLA to inhibit anxiety responses, as measured by the social interaction and conflict test.
Journal ArticleDOI
Corticotrophin Releasing Factor-Induced Synaptic Plasticity in the Amygdala Translates Stress into Emotional Disorders
Donald G. Rainnie,Richard Bergeron,Tammy J. Sajdyk,Madhvi Patil,Donald R. Gehlert,Anantha Shekhar +5 more
TL;DR: Results show for the first time a stress peptide-induced behavioral syndrome that can be correlated with cellular mechanisms of neural plasticity, a novel mechanism that may explain the etiological role of stress in several chronic psychiatric and medical disorders.