Jens Raila

TL;DR: It is demonstrated that megalin, an endocytic receptor in reproductive tissues, acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to sex hormone binding globulin.

TL;DR: DPP-4 inhibition on top of ARB treatment significantly reduced urinary albumin excretion and oxidative stress in diabetic eNOS knockout mice and may offer a new therapeutic approach for patients with diabetic nephropathy.

TL;DR: Existing human data showing elevated RBP4 levels in type 2 diabetic patients may be the result of moderate renal insufficiency rather than support for the suggestion thatRBP4 links obesity to type 2 diabetes.

TL;DR: The variability in the concentration was much greater in follicular fluid obtained from women without reproductive success, which remains to be elucidated, if this is indicative of a disturbed sieving effect of the blood-follicle barrier with possibly negative consequences for oocyte maturation.

TL;DR: This study suggests that plasma RBP4 levels in type 2 diabetic patients are affected by incipient nephropathy, and further studies evaluating RBP 4 as a regulator of systemic insulin resistance and type 2 diabetes will need to take renal function into consideration.