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Xudong Wu
Researcher at Tianjin Medical University
Publications - 49
Citations - 2229
Xudong Wu is an academic researcher from Tianjin Medical University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 16, co-authored 38 publications receiving 1639 citations. Previous affiliations of Xudong Wu include Tianjin Medical University General Hospital & University of Copenhagen.
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Journal ArticleDOI
Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide
TL;DR: The results show that it is the transcriptional state that governs PRC2 binding, and it is proposed that it binds by default to nontranscribed CGI genes to maintain their silenced state and to protect cell identity.
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Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation
TL;DR: It is shown that Fbxl10 interacts with Ring1B and Nspc1, forming a noncanonical PRC1 that is required for H2AK119ub1 in mouse ESCs and has a key role in regulating Ring1 B recruitment to its target genes and H2 AK119 ubiquitylation in ESCs.
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Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
Karin Klauke,Visnja Radulovic,Mathilde J.C. Broekhuis,Ellen Weersing,Erik Zwart,Sandra Olthof,Martha Ritsema,Sophia W.M. Bruggeman,Xudong Wu,Kristian Helin,Leonid Bystrykh,Gerald de Haan +11 more
TL;DR: It is shown that in the haematopoietic system this process is governed by polycomb chromobox (Cbx) proteins, and the presence of distinct Cbx proteins confers target selectivity to PRC1 and provides a molecular balance between self-renewal and differentiation of HSCs.
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FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS
Yawei Liu,Robert Carlsson,Manuel Comabella,Jun-Yang Wang,Michael Kosicki,Belinda Carrion,Maruf Hasan,Xudong Wu,Xavier Montalban,Morten Hanefeld Dziegiel,Finn Sellebjerg,Per Soelberg Sørensen,Kristian Helin,Shohreh Issazadeh-Navikas +13 more
TL;DR: The identification of FoxA1 as a transcription factor in T cells that, after ectopic expression, confers suppressive properties in a newly identified Treg cell population, herein called FoxA 1+ Treg cells is reported.
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Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity
Jie Yin,Jianmei W. Leavenworth,Yang Li,Qi Luo,Huafeng Xie,Xinhua Liu,Shan Huang,Han Yan,Zheng Fu,Liyun Y. Zhang,Litao Zhang,Junwei Hao,Xudong Wu,Xianming Deng,Charles W. M. Roberts,Stuart H. Orkin,Harvey Cantor,Xi Wang +17 more
TL;DR: Investigation of the impact of histone methylation repressive marks on early NK cell differentiation reveals an epigenetic-based mechanism that regulates NK cell development and provides insight into the clinical application of Ezh2 inhibitors in NK-based cancer immunotherapies.