J
Jeppe Sturis
Researcher at Novo Nordisk
Publications - 130
Citations - 10188
Jeppe Sturis is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 50, co-authored 126 publications receiving 9842 citations. Previous affiliations of Jeppe Sturis include University of Michigan & University of Illinois at Chicago.
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Journal ArticleDOI
Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance
TL;DR: It is shown that the volume of distribution and kinetic parameters of C-peptide distribution and metabolism vary by <30% in a population highly heterogenous in terms of age, sex, degree of obesity, and degree of glucose tolerance.
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Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.
TL;DR: These studies are reviewed and how insulin resistance and genetically programmed pancreatic beta-cell dysfunction may interact in susceptible persons to cause diabetes are suggested.
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One Week’s Treatment With the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and α- and β-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes
Kristine B. Degn,Claus B. Juhl,Jeppe Sturis,Grethe Jakobsen,Birgitte Brock,V. Chandramouli,Joergen Rungby,Bernard R. Landau,Ole Schmitz +8 more
TL;DR: 1 week's treatment with a single daily dose of the GLP-1 derivative liraglutide, operating through several different mechanisms including an ameliorated pancreatic islet cell function in individuals with type 2 diabetes, improves glycemic control throughout 24 h of daily living, i.e., prandial and nocturnal periods.
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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.
David A. Ehrmann,Jeppe Sturis,Maria M. Byrne,Theodore Karrison,Robert L. Rosenfield,Kenneth S. Polonsky +5 more
TL;DR: A history of NIDDM in a first-degree relative appears to define a subset of PCOS subjects with a greater prevalence of insulin secretory defects, which may enhance the risk of developing non-insulin-dependent diabetes mellitus among women with polycystic ovary syndrome.
Journal ArticleDOI
Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome
David A. Ehrmann,Melissa K. Cavaghan,Jacqueline Imperial,Jeppe Sturis,Robert L. Rosenfield,Kenneth S. Polonsky +5 more
TL;DR: It is concluded that hyperinsulinemia and androgen excess in obese nondiabetic women with PCOS are not improved by the administration of metformin.