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Jeppe Sturis

Researcher at Novo Nordisk

Publications -  130
Citations -  10188

Jeppe Sturis is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 50, co-authored 126 publications receiving 9842 citations. Previous affiliations of Jeppe Sturis include University of Michigan & University of Illinois at Chicago.

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Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

TL;DR: It is shown that the volume of distribution and kinetic parameters of C-peptide distribution and metabolism vary by <30% in a population highly heterogenous in terms of age, sex, degree of obesity, and degree of glucose tolerance.
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Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.

TL;DR: These studies are reviewed and how insulin resistance and genetically programmed pancreatic beta-cell dysfunction may interact in susceptible persons to cause diabetes are suggested.
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One Week’s Treatment With the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and α- and β-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes

TL;DR: 1 week's treatment with a single daily dose of the GLP-1 derivative liraglutide, operating through several different mechanisms including an ameliorated pancreatic islet cell function in individuals with type 2 diabetes, improves glycemic control throughout 24 h of daily living, i.e., prandial and nocturnal periods.
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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.

TL;DR: A history of NIDDM in a first-degree relative appears to define a subset of PCOS subjects with a greater prevalence of insulin secretory defects, which may enhance the risk of developing non-insulin-dependent diabetes mellitus among women with polycystic ovary syndrome.
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Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome

TL;DR: It is concluded that hyperinsulinemia and androgen excess in obese nondiabetic women with PCOS are not improved by the administration of metformin.