J
Jeremy E. Wilusz
Researcher at University of Pennsylvania
Publications - 65
Citations - 9191
Jeremy E. Wilusz is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: RNA & Circular RNA. The author has an hindex of 30, co-authored 56 publications receiving 7231 citations. Previous affiliations of Jeremy E. Wilusz include Johns Hopkins University & Watson School of Biological Sciences.
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Long noncoding RNAs: functional surprises from the RNA world
TL;DR: Most of the eukaryotic genome is transcribed, yielding a complex network of transcripts that includes tens of thousands of long noncoding RNAs with little or no protein-coding capacity.
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Short intronic repeat sequences facilitate circular RNA production
Dongming Liang,Jeremy E. Wilusz +1 more
TL;DR: Detailed and generalizable models that explain how the splicing machinery determines whether to produce a circular noncoding RNA or a linear mRNA are suggested.
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3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA
TL;DR: These findings reveal a 3' end processing mechanism by which a single gene locus can yield both a stable nuclear-retained noncoding RNA with a short poly(A) tail-like moiety and a small tRNA-like cytoplasmic RNA.
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MEN ε/β nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles
Hongjae Sunwoo,Marcel E. Dinger,Jeremy E. Wilusz,Paulo P. Amaral,John S. Mattick,David L. Spector +5 more
TL;DR: The findings indicate that the MEN epsilon/beta non-coding RNAs are essential structural/organizational components of paraspeckles.
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A triple helix stabilizes the 3′ ends of long noncoding RNAs that lack poly(A) tails
Jeremy E. Wilusz,Courtney K. JnBaptiste,Laura Lu,Claus-D. Kuhn,Leemor Joshua-Tor,Leemor Joshua-Tor,Phillip A. Sharp +6 more
TL;DR: It is found that a transcript ending in a triple helix is efficiently repressed by microRNAs in vivo, arguing against a major role for the poly(A) tail in microRNA-mediated silencing and suggest that RNA triple-helical structures likely have key regulatory functions in vivo.