D
David L. Spector
Researcher at Cold Spring Harbor Laboratory
Publications - 224
Citations - 33205
David L. Spector is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: RNA splicing & Cell nucleus. The author has an hindex of 84, co-authored 212 publications receiving 30451 citations. Previous affiliations of David L. Spector include Baylor College of Medicine & Rutgers University.
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Journal ArticleDOI
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
Masashi Narita,Sabrina Nuñez,Sabrina Nuñez,Edith Heard,Masako Narita,Athena W. Lin,Stephen Hearn,David L. Spector,Gregory J. Hannon,Scott W. Lowe +9 more
TL;DR: A distinct heterochromatic structure that accumulates in senescent human fibroblasts is described, which is designated senescence-associated heterochROMatic foci (SAHF) and is associated with the stable repression of E2F target genes.
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Long noncoding RNAs: functional surprises from the RNA world
TL;DR: Most of the eukaryotic genome is transcribed, yielding a complex network of transcripts that includes tens of thousands of long noncoding RNAs with little or no protein-coding capacity.
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The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Tony Gutschner,Monika Hämmerle,Moritz Eißmann,Jeff Hsu,Youngsoo Kim,Gene Hung,Alexey S. Revenko,Gayatri Arun,Marion Stentrup,Matthias Groß,Martin Zörnig,A. Robert MacLeod,David L. Spector,Sven Diederichs +13 more
TL;DR: A loss-of-function model unravels the active function of MALAT1 as a regulator of gene expression governing hallmarks of lung cancer metastasis with this ncRNA serving as both predictive marker and therapeutic target.
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Nuclear speckles: a model for nuclear organelles.
Angus I. Lamond,David L. Spector +1 more
TL;DR: Speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors and are located in the interchromatin regions of the nucleoplasm of mammalian cells, and can cycle continuously between speckles and other nuclear locations, including active transcription sites.
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Regulating Gene Expression through RNA Nuclear Retention
Kannanganattu V. Prasanth,Supriya G. Prasanth,Zhenyu Xuan,Stephen Hearn,Susan M. Freier,C. Frank Bennett,Michael Q. Zhang,David L. Spector +7 more
TL;DR: A role of the cell nucleus in harboring RNA molecules that are not immediately needed to produce proteins but whose cytoplasmic presence is rapidly required upon physiologic stress is revealed.