Jeremy Swann

TL;DR: This work provides the basis for further study of natural immunity to cancer and for rational use of this information in the design of immunotherapies in combination with other conventional cancer treatments.

TL;DR: It is demonstrated that equilibrium occurs, is mechanistically distinguishable from elimination and escape, and that neoplastic cells in equilibrium are transformed but proliferate poorly in vivo, and it is shown that tumour cells inilibrium are unedited but become edited when they spontaneously escape immune control and grow into clinically apparent tumours.

TL;DR: Data show that loss of RARgamma results in a nonhematopoietic cell-intrinsic MPS, revealing the capability of the microenvironment to be the sole cause of hematopOietic disorders.

TL;DR: CD4+CD25+ regulatory T cells (Treg) directly inhibit NKG2D-mediated NK cell cytotoxicity in vitro and in vivo, effectively suppressing NK cell-mediated tumor rejection.

TL;DR: It is shown that neutralization of NKG2D enhances the sensitivity of wild-type (WT) C57BL/6 and BALB/c mice to methylcholanthrene (MCA)-induced fibrosarcoma, and suggests an important early role for the NKG1D in controlling and shaping tumor formation.