J
Jerome B. Rattner
Researcher at University of Calgary
Publications - 109
Citations - 7470
Jerome B. Rattner is an academic researcher from University of Calgary. The author has contributed to research in topics: Centrosome & Microtubule. The author has an hindex of 44, co-authored 109 publications receiving 7016 citations.
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Journal ArticleDOI
Coupling of the nucleus and cytoplasm: Role of the LINC complex
Melissa Crisp,Qian Liu,Kyle J. Roux,Jerome B. Rattner,Catherine M. Shanahan,Brian Burke,Phillip D. Stahl,Didier Hodzic +7 more
TL;DR: Data from this study support a model in which Sun proteins tether nesprins in the ONM via interactions spanning the PNS, and form a complex that links the nucleoskeleton and cytoskeleton (the LINC complex).
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Cytoplasmic Dynein as a Facilitator of Nuclear Envelope Breakdown
TL;DR: A model in which dynein facilitates nuclear envelope breakdown by pulling nuclear membranes and associated proteins poleward along astral microtubules leading to nuclear membrane detachment is suggested.
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CDK5RAP2 Is a Pericentriolar Protein That Functions in Centrosomal Attachment of the γ-Tubulin Ring Complex
TL;DR: Together, CDK5RAP2 is a pericentriolar structural component that functions in gammaTuRC attachment and therefore in the microtubule organizing function of the centrosome, suggesting that centrosomes malfunction due to the CDK 5R AP2 mutations may underlie autosomal recessive primary microcephaly.
Journal ArticleDOI
Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells
TL;DR: The interactions amongst 20 proteins that specify their assembly to the centromere–kinetochore complex in human cells are reported and it is found that hMis12 is not constitutively localized at kinetochores, and that it is not essential for recruiting CENP-I.
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CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization.
TL;DR: Immune depletion experiments confirm that CENP-F exhibits the distribution pattern in cells that was seen with the native autoimmune serum, and closely parallels that of another high molecular weight kinetochore associated protein, C ENP-E.