J
Jerome Custers
Researcher at Janssen Pharmaceutica
Publications - 30
Citations - 1754
Jerome Custers is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Immunogenicity & Viral vector. The author has an hindex of 12, co-authored 30 publications receiving 1022 citations.
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Journal ArticleDOI
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
Noe B. Mercado,Roland Zahn,Frank Wegmann,Carolin Loos,Carolin Loos,Abishek Chandrashekar,Jingyou Yu,Jinyan Liu,Lauren Peter,Katherine McMahan,Lisa H. Tostanoski,Xuan He,David R. Martinez,Lucy Rutten,Rinke Bos,Danielle van Manen,Jort Vellinga,Jerome Custers,Johannes P. M. Langedijk,Ted Kwaks,Mark J. G. Bakkers,David Zuijdgeest,Sietske K. Rosendahl Huber,Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,John S. Burke,Jared Feldman,Jared Feldman,Blake M. Hauser,Blake M. Hauser,Timothy M. Caradonna,Timothy M. Caradonna,Esther A. Bondzie,Gabriel Dagotto,Gabriel Dagotto,Makda S. Gebre,Makda S. Gebre,Emily Hoffman,Catherine Jacob-Dolan,Catherine Jacob-Dolan,Marinela Kirilova,Zhenfeng Li,Zijin Lin,Shant H. Mahrokhian,Lori F. Maxfield,Felix Nampanya,Ramya Nityanandam,Joseph P. Nkolola,Shivani A. Patel,John D. Ventura,Kaylee Verrington,Huahua Wan,Laurent Pessaint,Alex Van Ry,Kelvin Blade,Amanda Strasbaugh,Mehtap Cabus,Renita Brown,Anthony L. Cook,Serge Zouantchangadou,Elyse Teow,Hanne Andersen,Mark G. Lewis,Yongfei Cai,Bing Chen,Aaron G. Schmidt,Aaron G. Schmidt,R. Keith Reeves,Ralph S. Baric,Douglas A. Lauffenburger,Galit Alter,Paul Stoffels,Mathai Mammen,Johan Van Hoof,Hanneke Schuitemaker,Dan H. Barouch +77 more
TL;DR: Robust single-shot vaccine protection against SARS-CoV-2 in nonhuman primates is demonstrated and vaccine-elicited neutralizing antibody titers correlated with protective efficacy, suggesting an immune correlate of protection.
Journal ArticleDOI
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.
Lisa H. Tostanoski,Frank Wegmann,Amanda J. Martinot,Amanda J. Martinot,Carolin Loos,Carolin Loos,Katherine McMahan,Noe B. Mercado,Jingyou Yu,Chi N. Chan,Stephen Bondoc,Carly E. Starke,Michael Nekorchuk,Kathleen Busman-Sahay,Cesar Piedra-Mora,Cesar Piedra-Mora,Linda M. Wrijil,Sarah Ducat,Jerome Custers,Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,John S. Burke,Jared Feldman,Jared Feldman,Blake M. Hauser,Blake M. Hauser,Timothy M. Caradonna,Timothy M. Caradonna,Esther A. Bondzie,Gabriel Dagotto,Gabriel Dagotto,Makda S. Gebre,Makda S. Gebre,Catherine Jacob-Dolan,Catherine Jacob-Dolan,Zijin Lin,Shant H. Mahrokhian,Felix Nampanya,Ramya Nityanandam,Laurent Pessaint,Maciel Porto,Vaneesha Ali,Dalia Benetiene,Komlan Tevi,Hanne Leth Andersen,Mark G. Lewis,Aaron G. Schmidt,Aaron G. Schmidt,Douglas A. Lauffenburger,Galit Alter,Jacob D. Estes,Hanneke Schuitemaker,Roland Zahn,Dan H. Barouch +55 more
TL;DR: It is shown that high-dose intranasal SARS-CoV-2 infection in hamsters results in severe clinical disease, including high levels of virus replication in tissues, extensive pneumonia, weight loss and mortality in a subset of animals.
Journal ArticleDOI
Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses.
Rinke Bos,Lucy Rutten,Joan E.M. van der Lubbe,Mark J. G. Bakkers,Gijs Hardenberg,Frank Wegmann,David Zuijdgeest,Adriaan H. de Wilde,Annemart Koornneef,Annemiek Verwilligen,Danielle van Manen,Ted Kwaks,Ronald Vogels,Tim J. Dalebout,Sebenzile K. Myeni,Marjolein Kikkert,Eric J. Snijder,Zhenfeng Li,Dan H. Barouch,Jort Vellinga,Johannes P. M. Langedijk,Roland Zahn,Jerome Custers,Hanneke Schuitemaker +23 more
TL;DR: In vitro characterization demonstrated that the introduction of stabilizing substitutions increased the ratio of neutralizing versus non-neutralizing antibody binding, suggestive for a prefusion conformation of the S protein, and the wild-type signal peptide was best suited for the correct cleavage needed for a natively folded protein.
Posted ContentDOI
Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses
Rinke Bos,Lucy Rutten,Joan E.M. van der Lubbe,Mark J. G. Bakkers,Gijs Hardenberg,Frank Wegmann,David Zuijdgeest,Adriaan H. de Wilde,Annemart Koornneef,Annemiek Verwilligen,Danielle van Manen,Ted Kwaks,Ronald Vogels,Tim J. Dalebout,Sebenzile K. Myeni,Marjolein Kikkert,Eric J. Snijder,Zhenfeng Li,Dan H. Barouch,Jort Vellinga,Johannes P. M. Langedijk,Roland Zahn,Jerome Custers,Hanneke Schuitemaker +23 more
TL;DR: In vitro characterization demonstrated that the introduction of stabilizing substitutions increased the ratio of neutralizing versus non-neutralizing antibody binding, suggestive for a prefusion conformation of the S protein, and the wild type signal peptide was best suited for the correct cleavage needed for a natively-folded protein.
Journal ArticleDOI
A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates
Benoit Callendret,Jort Vellinga,Kerstin Wunderlich,Ariane Rodriguez,Robin Steigerwald,Ulrike Dirmeier,Cédric Cheminay,Ariane Volkmann,Trevor Brasel,Ricardo Carrion,Luis D. Giavedoni,Jean L. Patterson,Chad E. Mire,Thomas W. Geisbert,Jay W. Hooper,Mo Weijtens,Jutta Sytske Hartkoorn-Pasma,Jerome Custers,Maria Grazia Pau,Hanneke Schuitemaker,Roland Zahn +20 more
TL;DR: The results demonstrate that it is feasible to generate a multivalent filov virus vaccine that can protect against lethal infection by multiple members of the filovirus family.