Z
Zijin Lin
Researcher at Beth Israel Deaconess Medical Center
Publications - 7
Citations - 2054
Zijin Lin is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Vaccination & Immunogenicity. The author has an hindex of 4, co-authored 5 publications receiving 1393 citations.
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Journal ArticleDOI
DNA vaccine protection against SARS-CoV-2 in rhesus macaques.
Jingyou Yu,Lisa H. Tostanoski,Lauren Peter,Noe B. Mercado,Katherine McMahan,Shant H. Mahrokhian,Joseph P. Nkolola,Jinyan Liu,Zhenfeng Li,Abishek Chandrashekar,David R. Martinez,Carolin Loos,Caroline Atyeo,Stephanie Fischinger,John S. Burke,Matthew D. Slein,Yuezhou Chen,Adam Zuiani,Felipe J.N. Lelis,Meghan Travers,Shaghayegh Habibi,Laurent Pessaint,Alex Van Ry,Kelvin Blade,Renita Brown,Anthony Cook,Brad Finneyfrock,Alan Dodson,Elyse Teow,Jason Velasco,Roland Zahn,Frank Wegmann,Esther A. Bondzie,Gabriel Dagotto,Makda S. Gebre,Xuan He,Catherine Jacob-Dolan,Marinela Kirilova,Nicole Kordana,Zijin Lin,Lori F. Maxfield,Felix Nampanya,Ramya Nityanandam,John D. Ventura,Huahua Wan,Yongfei Cai,Bing Chen,Aaron G. Schmidt,Duane R. Wesemann,Ralph S. Baric,Galit Alter,Hanne Andersen,Mark G. Lewis,Dan H. Barouch,Dan H. Barouch +54 more
TL;DR: Analysis of the vaccine candidates in rhesus macaques showed that animals developed protective humoral and cellular immune responses when challenged with the SARS-CoV-2 virus, suggesting an immune correlate of protection.
Journal ArticleDOI
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
Noe B. Mercado,Roland Zahn,Frank Wegmann,Carolin Loos,Carolin Loos,Abishek Chandrashekar,Jingyou Yu,Jinyan Liu,Lauren Peter,Katherine McMahan,Lisa H. Tostanoski,Xuan He,David R. Martinez,Lucy Rutten,Rinke Bos,Danielle van Manen,Jort Vellinga,Jerome Custers,Johannes P. M. Langedijk,Ted Kwaks,Mark J. G. Bakkers,David Zuijdgeest,Sietske K. Rosendahl Huber,Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,John S. Burke,Jared Feldman,Jared Feldman,Blake M. Hauser,Blake M. Hauser,Timothy M. Caradonna,Timothy M. Caradonna,Esther A. Bondzie,Gabriel Dagotto,Gabriel Dagotto,Makda S. Gebre,Makda S. Gebre,Emily Hoffman,Catherine Jacob-Dolan,Catherine Jacob-Dolan,Marinela Kirilova,Zhenfeng Li,Zijin Lin,Shant H. Mahrokhian,Lori F. Maxfield,Felix Nampanya,Ramya Nityanandam,Joseph P. Nkolola,Shivani A. Patel,John D. Ventura,Kaylee Verrington,Huahua Wan,Laurent Pessaint,Alex Van Ry,Kelvin Blade,Amanda Strasbaugh,Mehtap Cabus,Renita Brown,Anthony L. Cook,Serge Zouantchangadou,Elyse Teow,Hanne Andersen,Mark G. Lewis,Yongfei Cai,Bing Chen,Aaron G. Schmidt,Aaron G. Schmidt,R. Keith Reeves,Ralph S. Baric,Douglas A. Lauffenburger,Galit Alter,Paul Stoffels,Mathai Mammen,Johan Van Hoof,Hanneke Schuitemaker,Dan H. Barouch +77 more
TL;DR: Robust single-shot vaccine protection against SARS-CoV-2 in nonhuman primates is demonstrated and vaccine-elicited neutralizing antibody titers correlated with protective efficacy, suggesting an immune correlate of protection.
Journal ArticleDOI
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.
Lisa H. Tostanoski,Frank Wegmann,Amanda J. Martinot,Amanda J. Martinot,Carolin Loos,Carolin Loos,Katherine McMahan,Noe B. Mercado,Jingyou Yu,Chi N. Chan,Stephen Bondoc,Carly E. Starke,Michael Nekorchuk,Kathleen Busman-Sahay,Cesar Piedra-Mora,Cesar Piedra-Mora,Linda M. Wrijil,Sarah Ducat,Jerome Custers,Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,John S. Burke,Jared Feldman,Jared Feldman,Blake M. Hauser,Blake M. Hauser,Timothy M. Caradonna,Timothy M. Caradonna,Esther A. Bondzie,Gabriel Dagotto,Gabriel Dagotto,Makda S. Gebre,Makda S. Gebre,Catherine Jacob-Dolan,Catherine Jacob-Dolan,Zijin Lin,Shant H. Mahrokhian,Felix Nampanya,Ramya Nityanandam,Laurent Pessaint,Maciel Porto,Vaneesha Ali,Dalia Benetiene,Komlan Tevi,Hanne Leth Andersen,Mark G. Lewis,Aaron G. Schmidt,Aaron G. Schmidt,Douglas A. Lauffenburger,Galit Alter,Jacob D. Estes,Hanneke Schuitemaker,Roland Zahn,Dan H. Barouch +55 more
TL;DR: It is shown that high-dose intranasal SARS-CoV-2 infection in hamsters results in severe clinical disease, including high levels of virus replication in tissues, extensive pneumonia, weight loss and mortality in a subset of animals.
Journal ArticleDOI
Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial.
Kathryn E. Stephenson,Kathryn E. Stephenson,Boris Julg,Boris Julg,Boris Julg,C Sabrina Tan,Rebecca Zash,Stephen R. Walsh,Charlotte-Paige Rolle,Ana N. Monczor,Sofia Lupo,Huub C. Gelderblom,Jessica L Ansel,Diane G. Kanjilal,Lori F. Maxfield,Joseph P. Nkolola,Erica N. Borducchi,Peter Abbink,Jinyan Liu,Lauren Peter,Abishek Chandrashekar,Ramya Nityanandam,Zijin Lin,Alessandra Setaro,Joseph Sapiente,Zhilin Chen,Lisa Sunner,Tyler Cassidy,Chelsey Bennett,Alicia Sato,Bryan T. Mayer,Alan S. Perelson,Allan C. deCamp,Frances Priddy,Kshitij Wagh,Elena E. Giorgi,Nicole L. Yates,Roberto C. Arduino,Edwin DeJesus,Georgia D. Tomaras,Michael S. Seaman,Bette T. Korber,Dan H. Barouch,Dan H. Barouch +43 more
TL;DR: In this article, the authors performed a single-center, randomized, double-blind, dose-escalation, placebo-controlled trial of a single administration of the HIV-1 V3-glycan-specific antibody PGT121.
Journal ArticleDOI
Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
Noe B. Mercado,Roland Zahn,Frank Wegmann,Carolin Loos,Carolin Loos,Abishek Chandrashekar,Jingyou Yu,Jinyan Liu,Lauren Peter,Katherine McMahan,Lisa H. Tostanoski,Xuan He,David R. Martinez,Lucy Rutten,Rinke Bos,Danielle van Manen,Jort Vellinga,Jerome Custers,Johannes P. M. Langedijk,Ted Kwaks,Mark J. G. Bakkers,David Zuijdgeest,Sietske K. Rosendahl Huber,Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,John S. Burke,Jared Feldman,Jared Feldman,Blake M. Hauser,Blake M. Hauser,Timothy M. Caradonna,Timothy M. Caradonna,Esther A. Bondzie,Gabriel Dagotto,Gabriel Dagotto,Makda S. Gebre,Makda S. Gebre,Emily Hoffman,Catherine Jacob-Dolan,Catherine Jacob-Dolan,Marinela Kirilova,Zhenfeng Li,Zijin Lin,Shant H. Mahrokhian,Lori F. Maxfield,Felix Nampanya,Ramya Nityanandam,Joseph P. Nkolola,Shivani A. Patel,John D. Ventura,Kaylee Verrington,Huahua Wan,Laurent Pessaint,Alex Van Ry,Kelvin Blade,Amanda Strasbaugh,Mehtap Cabus,Renita Brown,Anthony L. Cook,Serge Zouantchangadou,Elyse Teow,Hanne Leth Andersen,Mark G. Lewis,Yongfei Cai,Bing Chen,Aaron G. Schmidt,Aaron G. Schmidt,R. Keith Reeves,Ralph S. Baric,Douglas A. Lauffenburger,Galit Alter,Paul Stoffels,Mathai Mammen,Johan Van Hoof,Hanneke Schuitemaker,Dan H. Barouch +77 more