Jerrold L. Boxerman

TL;DR: A novel Monte Carlo model is developed with which the authors quantified the relationship between microscopic tissue parameters, NMR imaging parameters, and susceptibility contrast in vivo and demonstrated that spin echo functional images have greater microvascular sensitivity than gradient echo images, and that the specifics of the volume fraction and concentration dependence of transverse relaxivity change should allow for robust mapping of relative blood volume.

TL;DR: Comparisons between Monte Carlo simulations and experiments with polystyrene microspheres to demonstrate that enhanced relaxation can be explained quantitatively for both spin echo and gradient echo imaging experiments and show that several regimes of behavior exist, and that contrast dependence is quite different in these regimes.

TL;DR: For gliomas, rCBV estimation that correlates significantly with WHO tumor grade necessitates contrast extravasation correction.

TL;DR: The model and experimental results are in agreement and suggest that the intravascular spins account for the majority of fMRI signal change on T2*‐weighted images at 1.5 T.

TL;DR: The current document outlines consensus recommendations for a standardized Brain Tumor Imaging Protocol (BTIP), along with the scientific and practical justifications for these recommendations, resulting from a series of discussions between various experts involved in aspects of neuro-oncology neuroimaging for clinical trials.