J
Jessica Escoffier
Researcher at Centre national de la recherche scientifique
Publications - 7
Citations - 415
Jessica Escoffier is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Acrosome reaction & Sperm. The author has an hindex of 7, co-authored 7 publications receiving 349 citations. Previous affiliations of Jessica Escoffier include French Institute of Health and Medical Research & Joseph Fourier University.
Papers
More filters
Journal ArticleDOI
A Recurrent Deletion of DPY19L2 Causes Infertility in Man by Blocking Sperm Head Elongation and Acrosome Formation
Radu Harbuz,Radu Harbuz,Raoudha Zouari,Virginie Pierre,Virginie Pierre,Mariem Ben Khelifa,Mariem Ben Khelifa,Mahmoud Kharouf,Charles Coutton,Charles Coutton,Ghaya Merdassi,Farid Abada,Farid Abada,Jessica Escoffier,Yorgos Nikas,François Vialard,Isabelle Koscinski,Chema Triki,Nathalie Sermondade,Thérèse Schweitzer,Amel Zhioua,Fethi Zhioua,Habib Latrous,Lazhar Halouani,Marrakchi Ouafi,Mounir Makni,Pierre-Simon Jouk,Pierre-Simon Jouk,B. Sèle,Sylviane Hennebicq,Véronique Satre,Véronique Satre,Stéphane Viville,Christophe Arnoult,Christophe Arnoult,Joël Lunardi,Joël Lunardi,Pierre F. Ray,Pierre F. Ray +38 more
TL;DR: It is demonstrated that patients with globozoospermia have a homozygous deletion of DPY19L2, thus indicating that DPY 19L2 is necessary in men for sperm head elongation and acrosome formation and assigns a poor prognosis for the success of in vitro fertilization.
Journal ArticleDOI
Bi-allelic Mutations in ARMC2 Lead to Severe Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in Humans and Mice
Charles Coutton,Charles Coutton,Guillaume Martinez,Guillaume Martinez,Zine-Eddine Kherraf,Zine-Eddine Kherraf,Amir Amiri-Yekta,Amir Amiri-Yekta,Amir Amiri-Yekta,Magalie Boguenet,Antoine Saut,Xiaojin He,Feng Zhang,Marie Cristou-Kent,Jessica Escoffier,Marie Bidart,Véronique Satre,Véronique Satre,Béatrice Conne,Selima Fourati Ben Mustapha,Lazhar Halouani,Ouafi Marrakchi,Mounir Makni,Habib Latrous,Mahmoud Kharouf,Karin Pernet-Gallay,Mélanie Bonhivers,Sylviane Hennebicq,Sylviane Hennebicq,Nathalie Rives,Emmanuel Dulioust,Aminata Touré,Aminata Touré,Aminata Touré,H Gourabi,Yunxia Cao,Raoudha Zouari,Seyedeh Hanieh Hosseini,Serge Nef,Nicolas Thierry-Mieg,Christophe Arnoult,Pierre F. Ray,Pierre F. Ray +42 more
TL;DR: It is shown that bi-allelic mutations in ARMC2 cause male infertility in humans and mice by inducing a typical MMAF phenotype, indicating that this gene is necessary for sperm flagellum structure and assembly.
Journal ArticleDOI
Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice
Jessica Escoffier,Ikram Jemel,Akemi Tanemoto,Yoshitaka Taketomi,Christine Payré,Christelle Coatrieux,Hiroyasu Sato,Kei Yamamoto,Seiko Masuda,Karin Pernet-Gallay,Virginie Pierre,Shuntaro Hara,Makoto Murakami,Michel De Waard,Gérard Lambeau,Christophe Arnoult +15 more
TL;DR: It is demonstrated that mouse group X sPLA2 (mGX) is the major enzyme present in the acrosome of spermatozoa and that it is released in an active form during capacitation through spontaneous AR, highlighting a paracrine role for mGX in which the enzyme primes sperm for efficient fertilization and boosts premature AR of a likely phospholipid-damaged sperm subpopulation to eliminate suboptimal sperm from the pool available for fertilization.
Journal ArticleDOI
Expression, localization and functions in acrosome reaction and sperm motility of Ca(V)3.1 and Ca(V)3.2 channels in sperm cells: an evaluation from Ca(V)3.1 and Ca(V)3.2 deficient mice.
Jessica Escoffier,Sylvie Boisseau,Catherine Serres,Chien-Chang Chen,Daesoo Kim,Séverine Stamboulian,Hee-Sup Shin,Kevin P. Campbell,Michel De Waard,Christophe Arnoult,Christophe Arnoult +10 more
TL;DR: In sperm, it is demonstrated that in sperm, besides CaV3.2 channels, other types of VDCC are activated during the voltage‐dependent calcium influx of AR, these channels likely belonging to high‐voltage activated Ca2+ channels family.
Journal ArticleDOI
Snake venoms as a source of compounds modulating sperm physiology: secreted phospholipases A2 from Oxyuranus scutellatus scutellatus impact sperm motility, acrosome reaction and in vitro fertilization in mice.
Jessica Escoffier,Morgane Couvet,Morgane Couvet,Harold de Pomyers,Pierre F. Ray,Michel Seve,Michel Seve,Gérard Lambeau,Gérard Lambeau,Michel De Waard,Michel De Waard,Christophe Arnoult,Christophe Arnoult,Christophe Arnoult +13 more
TL;DR: This is the first report characterizing sPLA(2) toxins that modulate in vitro sperm physiology and it is reported that sperm treated with OS2 were less competent than control sperm to initiate in vitro normal embryo development.