N
Nicolas Thierry-Mieg
Researcher at University of Grenoble
Publications - 55
Citations - 3993
Nicolas Thierry-Mieg is an academic researcher from University of Grenoble. The author has contributed to research in topics: Male infertility & Sperm. The author has an hindex of 24, co-authored 45 publications receiving 3232 citations. Previous affiliations of Nicolas Thierry-Mieg include Centre national de la recherche scientifique & Joseph Fourier University.
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Journal ArticleDOI
Protein Interaction Mapping in C. elegans Using Proteins Involved in Vulval Development
Albertha J.M. Walhout,Raffaella Sordella,Xiaowei Lu,James L. Hartley,Gary F. Temple,Michael A. Brasch,Nicolas Thierry-Mieg,Marc Vidal +7 more
TL;DR: A protein interaction mapping project is now feasible for C. elegans on a genome-wide scale and should contribute to the understanding of molecular mechanisms in this organism and in human diseases.
Journal ArticleDOI
Proto-genes and de novo gene birth
Anne-Ruxandra Carvunis,Thomas Rolland,Ilan Wapinski,Michael A. Calderwood,Muhammed A. Yildirim,Nicolas Simonis,Nicolas Simonis,Benoit Charloteaux,Benoit Charloteaux,César A. Hidalgo,Justin Barbette,Balaji Santhanam,Gloria A. Brar,Jonathan S. Weissman,Aviv Regev,Aviv Regev,Nicolas Thierry-Mieg,Michael E. Cusick,Marc Vidal +18 more
TL;DR: In this article, the authors formalize an evolutionary model according to which functional genes evolve de novo through transitory proto-genes generated by widespread translational activity in non-genic sequences.
Journal ArticleDOI
Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.
Mariem Ben Khelifa,Mariem Ben Khelifa,Mariem Ben Khelifa,Charles Coutton,Charles Coutton,Raoudha Zouari,Thomas Karaouzène,Thomas Karaouzène,John Rendu,John Rendu,Marie Bidart,Marie Bidart,Sandra Yassine,Sandra Yassine,Virginie Pierre,Virginie Pierre,Julie Delaroche,Julie Delaroche,Sylviane Hennebicq,Sylviane Hennebicq,Didier Grunwald,Didier Grunwald,Denise Escalier,Karine Pernet-Gallay,Karine Pernet-Gallay,Pierre-Simon Jouk,Nicolas Thierry-Mieg,Aminata Touré,Aminata Touré,Aminata Touré,Christophe Arnoult,Christophe Arnoult,Pierre F. Ray,Pierre F. Ray +33 more
TL;DR: Infertility was the only symptom of primary ciliary dyskinesia observed in affected subjects, suggesting that DNAH1 function in cilium is not as critical as in sperm flagellum, and genetic etiology is likely in most cases.
Journal ArticleDOI
A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome.
Anne Davy,Anne Davy,Paul Bello,Nicolas Thierry-Mieg,Philippe Vaglio,Joseph Hitti,Lynn Doucette-Stamm,Danielle Thierry-Mieg,Jérôme Reboul,Simon J. Boulton,Albertha J.M. Walhout,Olivier Coux,Marc Vidal +12 more
TL;DR: A two‐hybrid‐based protein interaction map was generated and novel potential proteasome interactors were identified, including an E3 ubiquitin ligase, transcription factors, chaperone proteins and other proteins not yet functionally annotated.
Journal ArticleDOI
Open-reading-frame sequence tags (OSTs) support the existence of at least 17,300 genes in C. elegans.
Jérôme Reboul,Philippe Vaglio,Nia Tzellas,Nicolas Thierry-Mieg,Troy Moore,Cindy Jackson,Tadasu Shin-I,Yuji Kohara,Danielle Thierry-Mieg,Jean Thierry-Mieg,Hongmei Lee,Joseph Hitti,Lynn Doucette-Stamm,James L. Hartley,Gary F. Temple,Michael A. Brasch,Jean Vandenhaute,Philippe Lamesch,Philippe Lamesch,David E. Hill,Marc Vidal +20 more
TL;DR: Experimental evidence is provided that supports the existence of at least 17,300 genes in C. elegans, suggesting that gene counts based primarily on ESTs may underestimate the number of genes in human and in other organisms.