J
Jessica L. Gray
Researcher at University of Alabama
Publications - 7
Citations - 77
Jessica L. Gray is an academic researcher from University of Alabama. The author has contributed to research in topics: Ruthenium & Hydrogen bond. The author has an hindex of 3, co-authored 7 publications receiving 43 citations.
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Journal ArticleDOI
Ruthenium Complexes are pH-Activated Metallo Prodrugs (pHAMPs) with Light-Triggered Selective Toxicity Toward Cancer Cells
Fengrui Qu,Seungjo Park,Kristina Martinez,Jessica L. Gray,Fathima Shazna Thowfeik,John A. Lundeen,Ashley E. Kuhn,David J. Charboneau,David J. Charboneau,Deidra L. Gerlach,Molly M. Lockart,James A. Law,Katherine L. Jernigan,Nicole Chambers,Matthias Zeller,Nicholas A. Piro,W. Scott Kassel,Russell H. Schmehl,Jared J. Paul,Edward J. Merino,Yonghyun Kim,Elizabeth T. Papish +21 more
TL;DR: A new class of pH-activated metallo prodrugs (pHAMPs) that are activated by light- and pH-triggered ligand dissociation are reported, establishing that a pHAMP approach can be used for selective targeting of cancer cells.
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Singlet Oxygen Formation vs Photodissociation for Light-Responsive Protic Ruthenium Anticancer Compounds: The Oxygenated Substituent Determines Which Pathway Dominates.
Fengrui Qu,Robert W. Lamb,Colin G. Cameron,Seungjo Park,Olaitan E. Oladipupo,Jessica L. Gray,Yifei Xu,Houston D. Cole,Marco Bonizzoni,Yonghyun Kim,Sherri A. McFarland,Charles Edwin Webster,Elizabeth T. Papish +12 more
TL;DR: In this paper, the authors show that the presence of a low lying triplet metal-centered (3MC) state favors photodissociation and disfavors 1O2 formation for 2A and 3A (OH groups).
Journal ArticleDOI
Cellular uptake of protic ruthenium complexes is influenced by pH dependent passive diffusion and energy dependent efflux.
Seungjo Park,Jessica L. Gray,Sarah D. Altman,Angela R. Hairston,Brianna T. Beswick,Yonghyun Kim,Elizabeth T. Papish +6 more
TL;DR: Data shows that uptake is required for toxicity but uptake alone is not sufficient and improved uptake by passive diffusion is expected with protic ligands on Ru(II); the greatest light activated toxicity appears to occur in breast cancer cell lines with relatively moderate uptake.
Journal ArticleDOI
Light-responsive and Protic Ruthenium Compounds Bearing Bathophenanthroline and Dihydroxybipyridine Ligands Achieve Nanomolar Toxicity towards Breast Cancer Cells†.
Olaitan E. Oladipupo,Spenser R. Brown,Robert W. Lamb,Robert W. Lamb,Jessica L. Gray,Colin G. Cameron,Alexa R. DeRegnaucourt,Nicholas A. Ward,James Fletcher Hall,Yifei Xu,Courtney M. Petersen,Fengrui Qu,Ambar B. Shrestha,Matthew K. Thompson,Marco Bonizzoni,Charles Edwin Webster,Sherri A. McFarland,Yonghyun Kim,Elizabeth T. Papish +18 more
TL;DR: In this paper, the authors report new ruthenium complexes bearing the lipophilic bathophenanthroline (BPhen) ligand and dihydroxybipyridine (dhbp) ligands which differ in the placement of the OH groups with n = 6 and 4 in 1A and 2A, respectively.
Journal ArticleDOI
Crystal structure of (perchlorato-κO)(1,4,7,10-tetraazacyclododecane-κ4N)copper(II) perchlorate
TL;DR: The crystal structure of (perchlorato-κO)(1,4,7,10-tetraazacyclodododecane-κ4 N)copper(II) perchlorate is reported, which was grown from a solution of methanol at ambient temperature which resulted in no co-crystallization of solvent.