J
Jessica L. L. Robinson
Researcher at University of Cambridge
Publications - 14
Citations - 1664
Jessica L. L. Robinson is an academic researcher from University of Cambridge. The author has contributed to research in topics: FOXA1 & Androgen receptor. The author has an hindex of 10, co-authored 14 publications receiving 1443 citations. Previous affiliations of Jessica L. L. Robinson include Edgewood College.
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Journal ArticleDOI
Progesterone receptor modulates ERα action in breast cancer
Hisham Mohammed,I. Alasdair Russell,Rory Stark,Oscar M. Rueda,Theresa E. Hickey,Gerard A. Tarulli,Aurélien A. Sérandour,Stephen N. Birrell,Alejandra Bruna,Amel Saadi,Suraj Menon,James Hadfield,Michelle Pugh,Ganesh V. Raj,Gordon D Brown,Clive D'Santos,Jessica L. L. Robinson,Grace O. Silva,Rosalind Launchbury,Charles M. Perou,John Stingl,Carlos Caldas,Wayne D. Tilley,Jason S. Carroll +23 more
TL;DR: Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis as mentioned in this paper, which has important implications for prognosis and therapeutic interventions.
Journal ArticleDOI
Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.
Hisham Mohammed,Clive D'Santos,Aurélien A. Sérandour,H. Raza Ali,Gordon D. Brown,Alan Atkins,Oscar M. Rueda,Kelly A. Holmes,Vasiliki Theodorou,Jessica L. L. Robinson,Wilbert Zwart,Amel Saadi,Caryn S. Ross-Innes,Suet-Feung Chin,Suraj Menon,John Stingl,Carlo Palmieri,Carlos Caldas,Jason S. Carroll +18 more
TL;DR: Findings reveal an unexpected role for GREB1 as an estrogen-specific ER cofactor that is expressed in drug-sensitive contexts, and predicts good clinical outcome.
Journal ArticleDOI
Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
Jessica L. L. Robinson,Stewart MacArthur,Caryn S. Ross-Innes,Wayne D. Tilley,David E. Neal,Ian G. Mills,Jason S. Carroll +6 more
TL;DR: Findings show that AR binds and regulates ER cis‐regulatory elements in molecular apocrine tumours, resulting in a transcriptional programme reminiscent of ER‐mediated transcription in luminal breast cancers.
Journal ArticleDOI
Minireview: The Androgen Receptor in Breast Tissues: Growth Inhibitor, Tumor Suppressor, Oncogene?
TL;DR: Understanding the molecular mechanisms whereby androgens can elicit distinct gene expression programs and opposing proliferative responses in these two breast cancer phenotypes is critical to the development of new therapeutic strategies to target the AR in breast cancer.
Journal ArticleDOI
Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype
Jessica L. L. Robinson,Theresa E. Hickey,Anne Y. Warren,Sarah L. Vowler,Thomas L. Carroll,Alastair D. Lamb,Nikolaos Papoutsoglou,David E. Neal,Wayne D. Tilley,Jason S. Carroll +9 more
TL;DR: Results suggest that in an androgen-depleted state, elevated levels of FOXA1 enhance AR binding at genomic regions not normally occupied by AR, which in turn facilitates prostate cancer cell growth.