S
Suraj Menon
Researcher at University of Cambridge
Publications - 24
Citations - 3054
Suraj Menon is an academic researcher from University of Cambridge. The author has contributed to research in topics: Transcription factor & Androgen receptor. The author has an hindex of 18, co-authored 24 publications receiving 2534 citations. Previous affiliations of Suraj Menon include AstraZeneca & Cardiff University.
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Journal ArticleDOI
Effect of Mutation Order on Myeloproliferative Neoplasms
Christina A. Ortmann,David G. Kent,Jyoti Nangalia,Yvonne Silber,David C. Wedge,Jacob Grinfeld,E. Joanna Baxter,Charles E. Massie,Elli Papaemmanuil,Suraj Menon,Anna L. Godfrey,Danai Dimitropoulou,Paola Guglielmelli,Beatriz Bellosillo,Carles Besses,Konstanze Döhner,Claire N. Harrison,George S. Vassiliou,Alessandro M. Vannucchi,Peter J. Campbell,Anthony R. Green +20 more
TL;DR: The order in which JAK2 and TET2 mutations were acquired influenced clinical features, the response to targeted therapy, the biology of stem and progenitor cells, and clonal evolution in patients with myeloproliferative neoplasms.
Journal ArticleDOI
Progesterone receptor modulates ERα action in breast cancer
Hisham Mohammed,I. Alasdair Russell,Rory Stark,Oscar M. Rueda,Theresa E. Hickey,Gerard A. Tarulli,Aurélien A. Sérandour,Stephen N. Birrell,Alejandra Bruna,Amel Saadi,Suraj Menon,James Hadfield,Michelle Pugh,Ganesh V. Raj,Gordon D Brown,Clive D'Santos,Jessica L. L. Robinson,Grace O. Silva,Rosalind Launchbury,Charles M. Perou,John Stingl,Carlos Caldas,Wayne D. Tilley,Jason S. Carroll +23 more
TL;DR: Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis as mentioned in this paper, which has important implications for prognosis and therapeutic interventions.
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NOTCH1 mediates a switch between two distinct secretomes during senescence
Matthew Hoare,Yoko Ito,Tae-Won Kang,Michael P. Weekes,Nicholas J Matheson,Daniel A. Patten,Shishir Shetty,Aled Parry,Suraj Menon,Rafik Salama,Robin Antrobus,Kosuke Tomimatsu,William J. Howat,Paul J. Lehner,Lars Zender,Masashi Narita +15 more
TL;DR: It is shown that the dynamic alteration of NOTCH1 activity during senescence dictates a functional balance between these two distinct secretomes: one representing TGF-β and the other pro-inflammatory cytokines, highlighting that NotCH1 is a temporospatial controller of secretome composition.
Journal ArticleDOI
Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.
Hisham Mohammed,Clive D'Santos,Aurélien A. Sérandour,H. Raza Ali,Gordon D. Brown,Alan Atkins,Oscar M. Rueda,Kelly A. Holmes,Vasiliki Theodorou,Jessica L. L. Robinson,Wilbert Zwart,Amel Saadi,Caryn S. Ross-Innes,Suet-Feung Chin,Suraj Menon,John Stingl,Carlo Palmieri,Carlos Caldas,Jason S. Carroll +18 more
TL;DR: Findings reveal an unexpected role for GREB1 as an estrogen-specific ER cofactor that is expressed in drug-sensitive contexts, and predicts good clinical outcome.
Journal ArticleDOI
GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility
TL;DR: It is found that GATA3 is pivotal in mediating enhancer accessibility at regulatory regions involved in ESR1-mediated transcription, and may potentially explain the contribution of mutant-GATA3 in the heterogeneity of E SR1+ breast cancer.