D
David Sala
Researcher at Discovery Institute
Publications - 19
Citations - 2092
David Sala is an academic researcher from Discovery Institute. The author has contributed to research in topics: Skeletal muscle & Mitochondrion. The author has an hindex of 15, co-authored 18 publications receiving 1592 citations. Previous affiliations of David Sala include Carlos III Health Institute & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
David Sebastián,María Isabel Hernández-Alvarez,Jessica Segalés,Eleonora Sorianello,Juan Pablo Muñoz,David Sala,Aurélie Waget,Marc Liesa,José C. Paz,Peddinti Gopalacharyulu,Matej Orešič,Sara Pich,Rémy Burcelin,Manuel Palacín,Antonio Zorzano +14 more
TL;DR: This study provides an important description of a unique unexpected role of Mfn2 coordinating mitochondria and endoplasmic reticulum function, leading to modulation of insulin signaling and glucose homeostasis in vivo.
Journal ArticleDOI
STAT3 signaling controls satellite cell expansion and skeletal muscle repair
Matthew T. Tierney,Tufan Aydogdu,David Sala,Barbora Malecova,Sole Gatto,Pier Lorenzo Puri,Lucia Latella,Alessandra Sacco +7 more
TL;DR: The results of this study indicate that pharmacological manipulation of STAT3 activity can be used to counteract the functional exhaustion of satellite cells in pathological conditions, thereby maintaining the endogenous regenerative response and ameliorating muscle-wasting diseases.
Journal ArticleDOI
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
David Sebastián,David Sebastián,Eleonora Sorianello,Eleonora Sorianello,Jessica Segalés,Jessica Segalés,Andrea Irazoki,Vanessa Ruiz-Bonilla,David Sala,David Sala,Evarist Planet,Antoni Berenguer‐Llergo,Juan Pablo Muñoz,Juan Pablo Muñoz,Manuela Sánchez-Feutrie,Manuela Sánchez-Feutrie,Natàlia Plana,Natàlia Plana,María Isabel Hernández-Alvarez,María Isabel Hernández-Alvarez,Antonio L. Serrano,Manuel Palacín,Manuel Palacín,Antonio Zorzano,Antonio Zorzano +24 more
TL;DR: The findings reveal that Mfn2 repression in muscle during aging is a determinant for the inhibition of mitophagy and accumulation of damaged mitochondria and triggers the induction of a mitochondrial quality control pathway.
Journal ArticleDOI
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice
Pedro M. Quirós,Andrew J. Ramsay,David Sala,David Sala,Erika Fernandez-Vizarra,Francisco Rodríguez,Juan R. Peinado,María Soledad Fernández-García,José A. Vega,José Antonio Enríquez,José Antonio Enríquez,Antonio Zorzano,Antonio Zorzano,Carlos López-Otín +13 more
TL;DR: This study provides the first description of an unexpected role in energy metabolism for the metalloprotease OMA1 and reinforces the importance of mitochondrial quality control for normal metabolic function.
Journal ArticleDOI
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
María Isabel Hernández-Alvarez,David Sebastián,David Sebastián,Sara Vives,Saška Ivanova,Saška Ivanova,Paola Bartoccioni,Pamela A. Kakimoto,Natàlia Plana,Sonia R. Veiga,Vanessa Hernández,Nuno Vasconcelos,Gopal Peddinti,Anna Adrover,Mariona Jové,Reinald Pamplona,Isabel Gordaliza-Alaguero,Isabel Gordaliza-Alaguero,Enrique Calvo,Noemí Cabré,Rui E. Castro,Antonija Kuzmanic,Marie Boutant,David Sala,Tuulia Hyötyläinen,Matej Orešič,Joana Fort,Joana Fort,Ekaitz Errasti-Murugarren,Cecília M. P. Rodrigues,Modesto Orozco,Jorge Joven,Carles Cantó,Manuel Palacín,Manuel Palacín,Sonia Fernández-Veledo,Joan Vendrell,Antonio Zorzano,Antonio Zorzano +38 more
TL;DR: It is demonstrated that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease and binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrialosphatidylethanolamine (PE) synthesis.