J
Jesús Espada
Researcher at Cajal Institute
Publications - 69
Citations - 6732
Jesús Espada is an academic researcher from Cajal Institute. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 32, co-authored 68 publications receiving 6289 citations. Previous affiliations of Jesús Espada include Carlos III Health Institute & Autonomous University of Madrid.
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Journal ArticleDOI
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
Mario F. Fraga,Esteban Ballestar,Ana Villar-Garea,Manuel Boix-Chornet,Jesús Espada,Gunnar Schotta,Tiziana Bonaldi,Claire E. Haydon,Santiago Ropero,Kevin Petrie,N. Gopalakrishna Iyer,Alberto Pérez-Rosado,Enrique Calvo,Juan Antonio López,Amparo Cano,María José Calasanz,Dolors Colomer,Miguel A. Piris,Natalie G. Ahn,Natalie G. Ahn,Axel Imhof,Carlos Caldas,Thomas Jenuwein,Manel Esteller +23 more
TL;DR: It is found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4 early and accumulated during the tumorigenic process, which is a common hallmark of human tumor cells.
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Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling
Hector G. Palmer,José Manuel González-Sancho,Jesús Espada,Maria T. Berciano,Isabel Puig,Josep Baulida,Miguel Quintanilla,Amparo Cano,Antonio García de Herreros,Miguel Lafarga,Alberto Muñoz +10 more
TL;DR: 1α,25(OH)2D3 induces E-cadherin and modulates β-catenin–TCF-4 target genes in a manner opposite to that of β- catenin, promoting the differentiation of colon carcinoma cells.
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Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer
Oscar Aguilera,Mario F. Fraga,Esteban Ballestar,Maria F. Paz,Michel Herranz,Jesús Espada,José Miguel García,Alberto Muñoz,Manel Esteller,José Manuel González-Sancho +9 more
TL;DR: It is shown for the first time that another extracellular Wnt inhibitor, the DICKKOPF-1 (DKK-1) gene, is transcriptionally silenced by CpG island promoter hypermethylation in colon cancer cell lines, whereas treatment with the DNA-demethylating agent 5-aza-2-deoxycytidine restored DKK- 1 expression.
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Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
Esteban Ballestar,Maria F. Paz,Laura Valle,Susan Wei,Mario F. Fraga,Jesús Espada,Juan C. Cigudosa,Tim H M Huang,Manel Esteller +8 more
TL;DR: It is demonstrated that MBD association to methylated DNA serves to identify novel targets of epigenetic inactivation in human cancer and their potential to ‘catch’ new hypermethylated genes in cancer is supported.
Journal Article
Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.
TL;DR: Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion and is a promising candidate agent for future cancer therapies based on epigenetics.