A
Alberto Pérez-Rosado
Publications - 9
Citations - 2335
Alberto Pérez-Rosado is an academic researcher. The author has contributed to research in topics: Lymphoma & Diffuse large B-cell lymphoma. The author has an hindex of 9, co-authored 9 publications receiving 2194 citations.
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Journal ArticleDOI
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
Mario F. Fraga,Esteban Ballestar,Ana Villar-Garea,Manuel Boix-Chornet,Jesús Espada,Gunnar Schotta,Tiziana Bonaldi,Claire E. Haydon,Santiago Ropero,Kevin Petrie,N. Gopalakrishna Iyer,Alberto Pérez-Rosado,Enrique Calvo,Juan Antonio López,Amparo Cano,María José Calasanz,Dolors Colomer,Miguel A. Piris,Natalie G. Ahn,Natalie G. Ahn,Axel Imhof,Carlos Caldas,Thomas Jenuwein,Manel Esteller +23 more
TL;DR: It is found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4 early and accumulated during the tumorigenic process, which is a common hallmark of human tumor cells.
Journal ArticleDOI
Expression of the NF‐κB targets BCL2 and BIRC5/Survivin characterizes small B‐cell and aggressive B‐cell lymphomas, respectively
Lorraine Tracey,Alberto Pérez-Rosado,Maria J. Artiga,Francisca I. Camacho,Antonia Rodriguez,Nerea Martinez,Elena Ruiz-Ballesteros,Manuela Mollejo,Beatriz Martínez,Marta Cuadros,Juan F. García,Mark Lawler,Miguel A. Piris +12 more
TL;DR: Examination of expression profiling and tissue microarray studies of 209 and 323 non‐Hodgkin's lymphomas respectively, including the most frequent sub‐types of NHL, showed that NF‐κB activation is a common phenomenon in NHL, resulting in the expression of distinct sets of NF-κB target genes, depending on the cell context.
Journal ArticleDOI
Inactivation of the Lamin A/C Gene by CpG Island Promoter Hypermethylation in Hematologic Malignancies, and Its Association With Poor Survival in Nodal Diffuse Large B-Cell Lymphoma
Ruben Agrelo,Fernando Setien,Jesús Espada,Maria J. Artiga,Maria A Rodriguez,Alberto Pérez-Rosado,Abel Sánchez-Aguilera,Mario F. Fraga,Miguel A. Piris,Manel Esteller +9 more
TL;DR: In this article, the authors investigated the role of CpG island hypermethylation in lamin A/C silencing and its prognostic relevance in lymphoma and leukemia.
Journal ArticleDOI
Building an outcome predictor model for diffuse large B-cell lymphoma.
Ana-Isabel Sáez,Antonio-José Sáez,María-Jesús Artiga,Alberto Pérez-Rosado,Francisca-Inmaculada Camacho,Ana Díez,J. García,Máximo Fraga,Ramon Bosch,Silvia-María Rodríguez-Pinilla,Manuela Mollejo,Cristina Romero,Lydia Sanchez-Verde,Marina Pollán,Miguel A. Piris +14 more
TL;DR: A protein-expression-based outcome predictor for DLBCL that complements the information obtained from the use of the IPI, allowing patients to be assigned to different risk categories, and improves the capacity for predicting failure and survival.
Journal ArticleDOI
Abnormal PcG protein expression in Hodgkin's lymphoma. Relation with E2F6 and NFκB transcription factors
Margarita Sánchez-Beato,Esther María Sánchez Sánchez,Juan F. García,Alberto Pérez-Rosado,María C. Montoya,Mario F. Fraga,M Jesús Artiga,Mercedes Navarrete,Víctor Abraira,Manuel M. Morente,Manel Esteller,Haruhiko Koseki,Miguel Vidal,Miguel A. Piris +13 more
TL;DR: A large‐scale analysis of PcG protein expression was performed in 321 Hodgkin's lymphoma biopsies and in reactive lymphoid tissues using tissue microarrays to propose that the formation of transcription complexes with E2F6 may modify the functional status of P cG proteins in HSR cells.