J
Ji-Bin Peng
Researcher at University of Alabama at Birmingham
Publications - 64
Citations - 5851
Ji-Bin Peng is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: TRPV6 & Calcium. The author has an hindex of 32, co-authored 64 publications receiving 5482 citations. Previous affiliations of Ji-Bin Peng include Harvard University & University of Alabama.
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Journal ArticleDOI
The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins
Matthias A. Hediger,Michael F. Romero,Ji-Bin Peng,Andreas Rolfs,Hitomi Takanaga,Elspeth A. Bruford +5 more
TL;DR: The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series, which includes 43 families and 298 transporter genes.
Journal ArticleDOI
Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption
Ji-Bin Peng,Xing-Zhen Chen,Urs V. Berger,Peter M. Vassilev,Hiroyasu Tsukaguchi,Edward M. Brown,Matthias A. Hediger +6 more
TL;DR: The properties of a calcium transport protein (CaT1) cloned from rat duodenum using an expression cloning strategy in Xenopus laevis oocytes are reported, which likely plays a key role in the intestinal uptake of calcium.
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CaT1 manifests the pore properties of the calcium-release-activated calcium channel
TL;DR: The protein CaT1 (ref. 4), which has six membrane-spanning domains, exhibits the unique biophysical properties of ICRAC when expressed in mammalian cells and is proposed to be all or part of the I CRAC pore.
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Marked Disturbance of Calcium Homeostasis in Mice With Targeted Disruption of the Trpv6 Calcium Channel Gene
Suzy D.C. Bianco,Ji-Bin Peng,Hitomi Takanaga,Yoshiro Suzuki,Alessandra Crescenzi,Claudine H. Kos,Liyan Zhuang,Michael R. Freeman,Cecilia H. A. Gouveia,Jiangping Wu,Hongyu Luo,Theodora M. Mauro,Edward M. Brown,Matthias A. Hediger +13 more
TL;DR: The phenotype of mice with targeted disruption of the Trpv6 (Trpv 6 KO) epithelial calcium channel exhibit disordered Ca2+ homeostasis, including defective intestinal Ca2- absorption, decreased BMD, deficient weight gain, and reduced fertility.
Journal ArticleDOI
Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies.
Liyan Zhuang,Ji-Bin Peng,Ji-Bin Peng,Liqiang Tou,Hitomi Takanaga,Hitomi Takanaga,Rosalyn M. Adam,Matthias A. Hediger,Matthias A. Hediger,Michael R. Freeman +9 more
TL;DR: It is established for the first time that CaT1 localizes to the apical membrane of intestinal absorptive cells, thereby providing the first direct evidence that this protein is in fact an apical entry channel in the gastrointestinal tract.