J
Ji-Young Park
Researcher at Korea Research Institute of Bioscience and Biotechnology
Publications - 30
Citations - 1615
Ji-Young Park is an academic researcher from Korea Research Institute of Bioscience and Biotechnology. The author has contributed to research in topics: Neuraminidase & Tumor necrosis factor alpha. The author has an hindex of 15, co-authored 30 publications receiving 1191 citations.
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Journal ArticleDOI
Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition
Young Bae Ryu,Hyung Jae Jeong,Jang Hoon Kim,Young-Min Kim,Ji-Young Park,Doman Kim,Thi Thanh Hanh Naguyen,Su-Jin Park,Jong Sun Chang,Ki Hun Park,Mun Chual Rho,Woo Song Lee +11 more
TL;DR: More potent activity appeared to be associated with the presence of an apigenin moiety at position C-3′ of flavones, as biflavone had an effect on 3CLpro inhibitory activity.
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Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors.
Ji-Young Park,Heung Joo Yuk,Hyung Won Ryu,Su Hwan Lim,Kyung Su Kim,Ki Hun Park,Young Bae Ryu,Woo Song Lee +7 more
TL;DR: The results suggest B. papyrifera constituents as promising candidates for development into potential anti-coronaviral agents after investigating their structural features that were responsible for this selectivity.
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Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases
Ji-Young Park,Jang Hoon Kim,Young-Min Kim,Hyung Jae Jeong,Dae Wook Kim,Ki Hun Park,Hyung Jun Kwon,Su-Jin Park,Woo Song Lee,Young Bae Ryu +9 more
TL;DR: It is identified that all of the isolated tanshinones are good inhibitors of both cysteine proteases and these findings provide potential inhibitors for SARS-CoV viral infection and replication.
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Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV.
Ji-Young Park,Ko Jin A,Dae Wook Kim,Young-Min Kim,Hyung Jun Kwon,Hyung Jae Jeong,Cha Young Kim,Ki Hun Park,Woo Song Lee,Young Bae Ryu +9 more
TL;DR: Detailed protein-inhibitor mechanistic analysis of these species indicated that the chalcones exhibited competitive inhibition characteristics to the Sars-CoV 3CLpro, whereas noncompetitive inhibition was observed with the SARS- coV PLpro.
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Dieckol, a SARS-CoV 3CLpro inhibitor, isolated from the edible brown algae Ecklonia cava
Ji-Young Park,Jang Hoon Kim,Jung Min Kwon,Hyung-Jun Kwon,Hyung Jae Jeong,Young-Min Kim,Doman Kim,Woo Song Lee,Young Bae Ryu +8 more
TL;DR: Phlorotannins have been isolated and are the first of their type showing competitively inhibitory activity toward SARS-CoV 3CLpro, and Dieckol showed the most potent SARsCoV3CLpro trans/cis-cleavage inhibitory effects with high association rate.