J
Jia-Lun Chen
Researcher at Shanghai Jiao Tong University
Publications - 46
Citations - 3814
Jia-Lun Chen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Bone density & Single-nucleotide polymorphism. The author has an hindex of 20, co-authored 46 publications receiving 3446 citations. Previous affiliations of Jia-Lun Chen include Ruijin Hospital & Huazhong University of Science and Technology.
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Journal ArticleDOI
Prevalence and control of diabetes in Chinese adults.
Yu Xu,Limin Wang,Jiang He,Yufang Bi,Mian Li,Tiange Wang,Linhong Wang,Yong Jiang,Meng Dai,Jieli Lu,Min Xu,Yichong Li,Nan Hu,Jianhong Li,Shengquan Mi,Chung Shiuan Chen,Guangwei Li,Yiming Mu,Jiajun Zhao,Lingzhi Kong,Jia-Lun Chen,Shenghan Lai,Weiqing Wang,Wenhua Zhao,Guang Ning +24 more
TL;DR: The estimated prevalence of diabetes among a representative sample of Chinese adults was 11.6% and the prevalence of prediabetes was 50.1%, which indicates the importance of diabetes as a public health problem in China.
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A genome-wide association study identifies two new risk loci for Graves' disease.
Xun Chu,Chun-Ming Pan,Shuang-Xia Zhao,Jun Liang,Guan-Qi Gao,Xiao-Mei Zhang,Guo-Yue Yuan,Changgui Li,Li-Qiong Xue,Min Shen,Wei Liu,Fang Xie,Shao-Ying Yang,Haifeng Wang,Jing-Yi Shi,Weiwei Sun,Wen-Hua Du,Chun-Lin Zuo,Shi Jinxiu,Bing-Li Liu,Cui-Cui Guo,Ming Zhan,Zhaohui Gu,Xiao-Na Zhang,Fei Sun,Zhi-Quan Wang,Zhi-Yi Song,Cai-Yan Zou,Weihua Sun,Ting Guo,Huang-Ming Cao,Jun-Hua Ma,Bing Han,Ping Li,He Jiang,Qiu-Hua Huang,Liming Liang,Libin Liu,Gang Chen,Qing Su,Yongde Peng,Jiajun Zhao,Guang Ning,Zhu Chen,Jia-Lun Chen,Sai-Juan Chen,Wei Huang,Huai-Dong Song +47 more
TL;DR: Strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease are identified.
Journal ArticleDOI
Berberine stimulates glucose transport through a mechanism distinct from insulin.
Libin Zhou,Ying Yang,Xiao Wang,Shangquan Liu,Wenbin Shang,Guoyue Yuan,Fengying Li,Jinfeng Tang,Ming-Dao Chen,Jia-Lun Chen +9 more
TL;DR: It was revealed that berberine stimulated glucose uptake in 3T3-L1 adipocytes in a dose- and time-dependent manner with the maximal effect at 12 hours, and activated adenosine monophosphate-activated protein kinase seems to be involved in the metabolic effect of berberines.
Journal ArticleDOI
A genome-wide search for type II diabetes susceptibility genes in Chinese Hans.
TL;DR: The results suggest that chromosome 9 contains genes involved in the susceptibility to Type II diabetes in an eastern and southeastern Chinese Han population, and chromosome 20 could hide genes linked to Type Two diabetes in families with a lower BMI.
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The influence of Lys3Asn polymorphism in the osteoprotegerin gene on bone mineral density in Chinese postmenopausal women
Hong-yan Zhao,Jian-min Liu,Guang Ning,Yong-ju Zhao,Lian-zhen Zhang,Li-hao Sun,Man-yin Xu,André G. Uitterlinden,Jia-Lun Chen +8 more
TL;DR: The OPG genotype Lys-Lys had a 2.7 times greater risk for osteopenia/osteoporosis than the Asn-Asn genotype, and the Lys3Asn polymorphism in the OPG gene is associated with L2–4 BMD in postmenopausal women.