J
Jialiang Huang
Researcher at Xiamen University
Publications - 42
Citations - 1525
Jialiang Huang is an academic researcher from Xiamen University. The author has contributed to research in topics: Chromatin & Enhancer. The author has an hindex of 18, co-authored 33 publications receiving 1150 citations. Previous affiliations of Jialiang Huang include GlaxoSmithKline & Chinese Academy of Sciences.
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Journal ArticleDOI
Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis
Jialiang Huang,Xin Liu,Dan Li,Zhen Shao,Hui Cao,Yuannyu Zhang,Yuannyu Zhang,Eirini Trompouki,Teresa V. Bowman,Leonard I. Zon,Leonard I. Zon,Guo-Cheng Yuan,Stuart H. Orkin,Stuart H. Orkin,Jian Xu +14 more
TL;DR: Comparing the enhancer landscape, transcriptional factor occupancy, and transcriptomic changes in human fetal and adult hematopoietic stem/progenitor cells and committed erythroid progenitors finds that enhancers are modulated pervasively and direct lineage- and stage-specific transcription.
Journal ArticleDOI
Dissecting super-enhancer hierarchy based on chromatin interactions.
Jialiang Huang,Kailong Li,Wenqing Cai,Xin Liu,Yuannyu Zhang,Stuart H. Orkin,Stuart H. Orkin,Jian Xu,Guo-Cheng Yuan +8 more
TL;DR: An integrative analysis of Hi-C and ChIP-seq data finds that a significant fraction of SEs are hierarchically organized, containing both hub and non-hub enhancers.
Journal ArticleDOI
Systematic prediction of pharmacodynamic drug-drug interactions through protein-protein-interaction network.
Jialiang Huang,Jialiang Huang,Jialiang Huang,Chaoqun Niu,Chaoqun Niu,Christopher D. Green,Lun Yang,Hongkang Mei,Jing-Dong J. Han +8 more
TL;DR: A metric “S-score” is developed that measures the strength of network connection between drug targets to predict PD DDIs and observed a significant correlation between S-score and the likelihood a PD DDI occurs.
Journal ArticleDOI
Developmental control of Polycomb subunit composition by GATA factors mediates a switch to non-canonical functions
Jian Xu,Jian Xu,Zhen Shao,Zhen Shao,Dan Li,Huafeng Xie,Woojin Kim,Jialiang Huang,Jordan E. Taylor,Luca Pinello,Kimberly Glass,Jacob D. Jaffe,Guo-Cheng Yuan,Stuart H. Orkin,Stuart H. Orkin +14 more
TL;DR: The lineage- and developmental stage-specific regulation of PRC2 subunit composition leads to a switch from canonical silencing to non-canonical functions during blood stem cell specification.
Journal ArticleDOI
Predicting chromatin organization using histone marks.
TL;DR: A computational model integrating Hi-C and histone mark ChIP-seq data to predict two important features of chromatin organization: chromatin interaction hubs and topologically associated domain (TAD) boundaries is developed and accurately and robustly predicts these features across datasets and cell types.