Xin Liu

TL;DR: A high-resolution X-ray crystal structure of a semi-synthetic heterodimeric p300 HAT domain in complex with a bi-substrate inhibitor, Lys-CoA is described, showing that p300/CBP is a distant cousin of other structurally characterized HATs, but reveals several novel features that explain the broad substrate specificity and preference for nearby basic residues.

TL;DR: This study provides a model describing the signaling network involved in maintaining the long-term survival of competent CTL in humans and suggests that the persistence of IL-15 and PDGF is sufficient to reproduce all known deregulations in leukemic T-LGL.

TL;DR: Gain-of-function studies establish the integral role for NANOG in neoplastic processes and shed light on its mechanisms of action in tumorigenesis, as well as establishing the importance of CXCR4, IGFBP5, CD133 and ALDH1 in this work.

TL;DR: The crystal structures of an active PRC2 complex of 170 kD from the fungus Chaetomium thermophilum are reported, with an S-adenosyl-l-homocysteine cofactor and an inhibiting H3K27M cancer mutant peptide bound to the catalytic SET domain of Ezh2 were captured in the crystal structure of both basal and stimulated complexes.

TL;DR: This study suggests that PSA(-/lo) cells may represent a critical source of castration-resistant PCa cells.