J
Jiamei Chen
Researcher at Guangzhou University of Chinese Medicine
Publications - 8
Citations - 109
Jiamei Chen is an academic researcher from Guangzhou University of Chinese Medicine. The author has contributed to research in topics: Sulfation & Acacetin. The author has an hindex of 6, co-authored 8 publications receiving 89 citations. Previous affiliations of Jiamei Chen include Macau University of Science and Technology.
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Journal ArticleDOI
Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients
Tongmeng Yan,Linlin Lu,Cong Xie,Jiamei Chen,Xiao-Juan Peng,Lijun Zhu,Ying Wang,Qiang Li,Jian Shi,Fuyuan Zhou,Ming Hu,Zhongqiu Liu,Zhongqiu Liu +12 more
TL;DR: It is proposed that determination of the CYP protein expression profile by LC/MS-MS in each patient is a promising approach that can be clinically used for individualized treatment of HCC.
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LC-MS/MS quantification of sulfotransferases is better than conventional immunogenic methods in determining human liver SULT activities: implication in precision medicine
Cong Xie,Cong Xie,Tongmeng Yan,Tongmeng Yan,Jiamei Chen,Xiaoyan Li,Juan Zou,Lijun Zhu,Linlin Lu,Ying Wang,Fuyuan Zhou,Fuyuan Zhou,Zhongqiu Liu,Zhongqiu Liu,Ming Hu +14 more
TL;DR: LC-MS/MS quantification of Sults is highly reliable measurement of SULT activities, and may be adopted for implementing precision medicine with respect to drugs mainly metabolized by SULTs in healthy and HCC patients.
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Profiles and Gender-Specifics of UDP-Glucuronosyltransferases and Sulfotransferases Expressions in the Major Metabolic Organs of Wild-Type and Efflux Transporter Knockout FVB Mice
Jiamei Chen,Haihui Zheng,Sijing Zeng,Cong Xie,Xiaoyan Li,Tongmeng Yan,Xia Gong,Linlin Lu,Xiaoxiao Qi,Ying Wang,Ming Hu,Ming Hu,Lijun Zhu,Zhongqiu Liu,Zhongqiu Liu +14 more
TL;DR: A better understanding of the expression profiles and gender-specific of Ugts and Sults in major metabolic organs of WT and efflux transporter KO mice is useful for the evaluation of potential efficacy, and toxicity of corresponding substrates.
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Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides
Huangyu Jiang,Jia Yu,Haihui Zheng,Jiamei Chen,Jinjun Wu,Xiaoxiao Qi,Ying Wang,Xinchun Wang,Ming Hu,Ming Hu,Lijun Zhu,Zhongqiu Liu,Zhongqiu Liu +12 more
TL;DR: The coupling of glucuronidation and efflux transport was probably the primary reason for the low bioavailability of acacetin.
Journal ArticleDOI
Sulfotransferases and Breast Cancer Resistance Protein Determine the Disposition of Calycosin in Vitro and in Vivo
Jia Yu,Lijun Zhu,Haihui Zheng,Xia Gong,Huangyu Jiang,Jiamei Chen,Yuhuan Li,Hongming Zheng,Xiaoxiao Qi,Ying Wang,Ming Hu,Ming Hu,Linlin Lu,Zhongqiu Liu,Zhongqiu Liu +14 more
TL;DR: It is confirmed that sulfate conjugate is breast cancer resistance protein (BCRP) substrate using the intestinal perfusion model and pharmacokinetics studies in Bcrp1-/- mice and BCRP is a critical determinant to the disposition of C-3'-S.