Jian-Min Sun

TL;DR: H4-K16Ac inhibits the ability of the adenosine triphosphate–utilizing chromatin assembly and remodeling enzyme ACF to mobilize a mononucleosome, indicating that this single histone modification modulates both higher order chromatin structure and functional interactions between a nonhistone protein and the chromatin fiber.

TL;DR: It is proposed that Mad-Max functions by recruiting the mSin3-HDAC corepressor complex that deacetylates nucleosomal histones, producing alterations in chromatin structure that block transcription.

TL;DR: Several human cDNAs encoding a histone deacetylase protein, HDAC3, have been isolated and analysis of the predicted amino acid sequence revealed an open reading frame of 428 amino acids with a predicted molecular mass of 49 kDa.

TL;DR: This review focuses on the roles of Sp1 and Sp3 in the regulation of gene expression, and in vitro and in vivo studies reveal that these transcription factors have strikingly different functions.

TL;DR: YY1 and LSF may establish transcriptional and virological latency of HIV, a state that has recently been recognized in vivo and has significant implications for the long-term treatment of AIDS.