F
Fredrik Ek
Researcher at Lund University
Publications - 20
Citations - 201
Fredrik Ek is an academic researcher from Lund University. The author has contributed to research in topics: Kinase & Synucleinopathies. The author has an hindex of 6, co-authored 20 publications receiving 171 citations. Previous affiliations of Fredrik Ek include ACADIA Pharmaceuticals Inc..
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Patent
Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
TL;DR: In this article, analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof are presented, and methods of using the analogs for treating neuropsychiatric disorders.
Journal ArticleDOI
Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists.
Hanna Pettersson,Anne Bulow,Fredrik Ek,Jacob Jensen,Lars Korsgaard Ottesen,Alma Fejzic,Jian Nong Ma,Andria L. Del Tredici,Erika A. Currier,Luis R. Gardell,Ali Tabatabaei,Darren Craig,Krista McFarland,Thomas R. Ott,Fabrice Piu,Ethan S. Burstein,Roger Olsson +16 more
TL;DR: A novel class of CB1 inverse agonists was discovered and a lead compound 11-(4-chlorophenyl)dibenzo[b,f][1,4]thiazepine-8-carboxylic acid butylamide (12e) which showed excellent in vivo activity in pharmacodynamic models related to CB1 receptor activity was discovered.
Patent
Bicyclic nitrogen compounds as modulators of ghrelin receptor and uses thereof
TL;DR: In this article, compounds of Formula I as defined herein, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, that modulates the activity of a ghrelin receptor are presented.
Journal ArticleDOI
Zeolite beta Induced Rearrangement of Allyl Benzyl Ethers. 6. Variation of the Aromatic Part and Synthesis of Dihydronaphthalene Derivatives.
TL;DR: The zeolite beta induced rearrangement of substituted allyl benzyl ethers to give 4-arylbutanals was investigated with respect to the substituents in the aromatic ring, and in some cases the resulting aldehydes cyclized spontaneously to give dihydronaphthalene derivatives.
Journal ArticleDOI
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Mark C. Wilkes,Kavitha Siva,Jianing Chen,G. Varetti,Minyoung Youn,Hee-Don Chae,Fredrik Ek,Roger Olsson,Thomas Lundbäck,Daniel P. Dever,Toshinobu Nishimura,Anupama Narla,Bertil Glader,Hiromitsu Nakauchi,Hiromitsu Nakauchi,Matt Porteus,Claire E. Repellin,Hanna T. Gazda,Hanna T. Gazda,Sijie Lin,Manuel Serrano,Johan Flygare,Kathleen M. Sakamoto +22 more
TL;DR: The role of Nemo-like kinase (NLK) in erythroid cells in the pathogenesis of DBA and as a potential target for therapy are examined.