Jian Yu

TL;DR: It is shown that CIN is consistently associated with the loss of function of a mitotic checkpoint in cancers displaying CIN, and in some cancersThe loss of this checkpoint wasassociated with the mutational inactivation of a human homologue of the yeast BUB1 gene; BUB 1 controls mitotic checkpoints and chromosome segregation in yeast.

TL;DR: Through global profiling of genes that were expressed soon after p53 expression, a novel gene termed PUMA (p53 upregulated modulator of apoptosis) was identified and it was found to be exclusively mitochondrial and to bind to Bcl-2 and Bcl(L) through a BH3 domain.

TL;DR: An unambiguous role for BAX in apoptotic processes in human epithelial cancers is established and may have implications for cancer chemoprevention strategies.

TL;DR: Molecular biologists ought to respect the original definition of synteny and its etymological derivation, especially as this term is still needed to refer to genes located on the same chromosome.

TL;DR: It is suggested that the balance between PUMA and p21 is pivotal in determining the responses to p53 activation and provide a model for understanding the basis of p53 mutations in human cancer.