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Andrea Alimonti
Researcher at University of Lugano
Publications - 78
Citations - 10392
Andrea Alimonti is an academic researcher from University of Lugano. The author has contributed to research in topics: Prostate cancer & PTEN. The author has an hindex of 29, co-authored 58 publications receiving 7998 citations. Previous affiliations of Andrea Alimonti include Harvard University & Kettering University.
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Journal ArticleDOI
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
Arkaitz Carracedo,Li Ma,Li Ma,Li Ma,Julie Teruya-Feldstein,Federico Rojo,Leonardo Salmena,Leonardo Salmena,Andrea Alimonti,Andrea Alimonti,Ainara Egia,Ainara Egia,Atsuo T. Sasaki,George Thomas,Sara C. Kozma,Antonella Papa,Antonella Papa,Caterina Nardella,Caterina Nardella,Lewis C. Cantley,José Baselga,Pier Paolo Pandolfi,Pier Paolo Pandolfi +22 more
TL;DR: MAPK activation as a consequence of mTORC1 inhibition is identified and the potential of a combined therapeutic approach with m TORC1 and MAPK inhibitors, currently employed as single agents in the clinic, for the treatment of human cancers is underscore.
Journal ArticleDOI
Cellular Senescence: Defining a Path Forward
Vassilis G. Gorgoulis,Peter D. Adams,Andrea Alimonti,Dorothy C. Bennett,Oliver Bischof,Cleo L. Bishop,Judith Campisi,Manuel Collado,Konstantinos Evangelou,Gerardo Ferbeyre,Jesús Gil,Eiji Hara,Valery Krizhanovsky,Diana Jurk,Andrea B. Maier,Masashi Narita,Laura J. Niedernhofer,João F. Passos,Paul D. Robbins,Clemens A. Schmitt,John M. Sedivy,Konstantinos Vougas,Thomas von Zglinicki,Daohong Zhou,Manuel Serrano,Marco Demaria +25 more
TL;DR: A consensus from the International Cell Senescence Association (ICSA) is presented, defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers.
Journal ArticleDOI
Ubiquitination regulates PTEN nuclear import and tumor suppression
Lloyd C. Trotman,Xinjiang Wang,Andrea Alimonti,Zhenbang Chen,Julie Teruya-Feldstein,Haijuan Yang,Nikola P. Pavletich,Brett S. Carver,Carlos Cordon-Cardo,Hediye Erdjument-Bromage,Paul Tempst,Sung Gil Chi,Hyo Jong Kim,Tom Misteli,Xuejun Jiang,Pier Paolo Pandolfi +15 more
TL;DR: It is shown that nuclear PTEN is essential for tumor suppression and that PTEN nuclear import is mediated by its monoubiquitination, and how a discrete molecular mechanism dictates tumor progression by differentiating between degradation and protection ofPTEN is demonstrated.
Journal ArticleDOI
NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN
Xinjiang Wang,Lloyd C. Trotman,Theresa M. Koppie,Andrea Alimonti,Zhenbang Chen,Zhonghua Gao,Junru Wang,Hediye Erdjument-Bromage,Paul Tempst,Carlos Cordon-Cardo,Pier Paolo Pandolfi,Xuejun Jiang +11 more
TL;DR: It is shown that PTEN level is regulated by ubiquitin-mediated proteasomal degradation, and purified its ubiquitIn ligase as HECT-domain protein NEDD4-1, a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53.
Journal ArticleDOI
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
Brett S. Carver,Jennifer Tran,Anuradha Gopalan,Zhenbang Chen,Zhenbang Chen,Safa Shaikh,Arkaitz Carracedo,Arkaitz Carracedo,Andrea Alimonti,Andrea Alimonti,Caterina Nardella,Caterina Nardella,Shohreh Varmeh,Shohreh Varmeh,Peter T. Scardino,Carlos Cordon-Cardo,William L. Gerald,Pier Paolo Pandolfi,Pier Paolo Pandolfi +18 more
TL;DR: ERG has a distinct role in prostate cancer progression and cooperates with PTEN haploinsufficiency to promote progression of HGPIN to invasive adenocarcinoma.