J
Jianmeng Chen
Researcher at Johns Hopkins University School of Medicine
Publications - 4
Citations - 143
Jianmeng Chen is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Pharmacodynamics & Pharmacokinetics. The author has an hindex of 4, co-authored 4 publications receiving 134 citations.
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Journal ArticleDOI
A Randomized Trial to Assess Anti-HIV Activity in Female Genital Tract Secretions and Soluble Mucosal Immunity Following Application of 1% Tenofovir Gel
Marla J. Keller,Rebecca Pellett Madan,N. Merna Torres,Melissa Fazzari,Sylvia Cho,Sabah Kalyoussef,Gail F. Shust,Pedro M. M. Mesquita,Nicolette A. Louissaint,Jianmeng Chen,Hillel W. Cohen,Erin C. Diament,Anna C. Lee,Lydia Soto-Torres,Craig W. Hendrix,Betsy C. Herold +15 more
TL;DR: In this paper, a double-blind, placebo-controlled trial of tenofovir gel, the first microbicide to demonstrate significant protection against HIV acquisition, was conducted.
Journal ArticleDOI
Biphasic elimination of tenofovir diphosphate and nonlinear pharmacokinetics of zidovudine triphosphate in a microdosing study.
Jianmeng Chen,Charles Flexner,Rosa G. Liberman,Paul L. Skipper,Nicolette A. Louissaint,Steven R. Tannenbaum,Craig W. Hendrix,Edward J. Fuchs +7 more
TL;DR: The authors' data were consistent with a rate-limiting step in the intracellular phosphorylation of ZDV but not TFV, and Accelerator mass spectrometry shows promise for predicting the PK of active intrACEllular metabolites of nucleosides, but nonlinearity of PK may be seen with some drugs.
Journal ArticleDOI
Pharmacokinetics and Placental Transfer of Single-Dose Tenofovir 1% Vaginal Gel in Term Pregnancy
Richard H. Beigi,Lisa M. Noguchi,Teresa L. Parsons,Ingrid Macio,Ratiya Pamela Kunjara Na Ayudhya,Jianmeng Chen,Craig W. Hendrix,Benoît Mâsse,Benoît Mâsse,Megan Valentine,Jeanna M. Piper,D. Heather Watts +11 more
TL;DR: Findings support ongoing and future investigations of TFV gel in pregnancy and support the found to decrease sexual transmission of human immunodeficiency virus.
Journal ArticleDOI
Accelerator mass spectrometry measurement of intracellular concentrations of active drug metabolites in human target cells in vivo.
Jianmeng Chen,R C Garner,Lawrence S. Lee,M Seymour,Edward J. Fuchs,W C Hubbard,Teresa L. Parsons,G E Pakes,Courtney V. Fletcher,Charles Flexner +9 more
TL;DR: AMS holds promise as a tool for quantifying intracellular drug metabolites and other biomediators in vivo and was 30,000‐fold more sensitive than LC/MS/MS.