Jianpeng Xu

TL;DR: In conclusion, inhibition of a specific tsRNA, LeuCAG3′tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-derived orthotopic hepatocellular carcinoma model in mice, establishing a post-transcriptional mechanism that can fine-tune gene expression during different physiological states and provide a potential new target for treating cancer.

TL;DR: Two of the evolved AAV serotypes exhibited dramatically improved functional human hepatocyte transduction in vivo in xenografted mice with human livers, along with favorable human seroreactivity profiles, compared with existing serotypes, and represent enhanced vector delivery systems for future human liver gene therapy applications.

TL;DR: The generation of a chimeric AAV capsid (AAV-KP1) that facilitates transduction of primary human islet cells and human embryonic stem cell-derived β cells with up to 10-fold higher efficiency compared with previously studied best-in-class AAV vectors is described.

TL;DR: The mouse liver microRNA landscape following depletion of miR-122 and the impact that this has on its target mRNAs is analysed to reveal a transcriptomic framework for the hepatic response to loss and the outcome on other microRNAs and their cognate gene targets.

TL;DR: The results suggest that LeuCAG3'tsRNA might maintain ribosome biogenesis through a conserved gene regulatory mechanism in vertebrates.