Gabriele Fuchs

TL;DR: A pooled CRISPR genetic screening strategy is used to comprehensively dissect host factors required for dengue virus and Hepatitis C virus, and finds an unexpected link between intracellular flavin adenine dinucleotide levels and HCV replication.

TL;DR: In conclusion, inhibition of a specific tsRNA, LeuCAG3′tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-derived orthotopic hepatocellular carcinoma model in mice, establishing a post-transcriptional mechanism that can fine-tune gene expression during different physiological states and provide a potential new target for treating cancer.

TL;DR: This work presents structures of unliganded Ro and Ro complexed with two RNAs at 1.95 and 2.2 A resolution, and suggests that one role of Y RNAs may be to regulate access of other RNAs to Ro.

TL;DR: Reduced expression of bone morphogenetic protein receptor 2 subverts a stress granule response, heightens GM-CSF mRNA translation, and increases inflammatory cell recruitment to exacerbate pulmonary arterial hypertension.

TL;DR: Opening the Pandora’s box on viral PTMs, this report presents numerous questions and hypotheses on PTM function and strongly supports PTMs as a new tier of regulation by which RNA viruses subvert the host and evade cellular surveillance systems.