J
Jianrong Li
Researcher at University of Arizona
Publications - 119
Citations - 7382
Jianrong Li is an academic researcher from University of Arizona. The author has contributed to research in topics: Nitric oxide & Axon. The author has an hindex of 42, co-authored 114 publications receiving 6794 citations. Previous affiliations of Jianrong Li include University of Hawaii & Boston Children's Hospital.
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Journal ArticleDOI
Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation
TL;DR: The concept that NO is an endogenous regulator of caspase activity is supported, with reports that of the seven caspases studied, all were reversibly inhibited by NO.
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Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
TL;DR: It is shown that lipopolysaccharide (LPS)-induced death of developing OLs is caused by microglia-derived peroxynitrite, the reaction product of nitric oxide (NO) and superoxide anion, and suggested that peroxlynitrite produced by iNOS and NADPH oxidase in activated microgla may play an important role in the pathogenesis of white matter disorders.
Journal ArticleDOI
Isolation and culture of rat and mouse oligodendrocyte precursor cells
Ying Chen,Veerakumar Balasubramaniyan,Jie Peng,Edward C. Hurlock,Michelle D. Tallquist,Jianrong Li,Q. Richard Lu +6 more
TL;DR: Simple and efficient methods for the preparation and in vitro maintenance of enriched OPCs from rats and mice are described.
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Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes
TL;DR: Evidence is provided for a key role for GPx-catalase cooperativity in the resistance of mature OLs to H2O2-induced cell death.
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The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination.
Ying Chen,Heng Wu,Shuzong Wang,Hisami Koito,Jianrong Li,Feng Ye,Jenny Hoang,Sabine S. Escobar,Alexander Gow,Heather A. Arnett,Bruce D. Trapp,Nitin J. Karandikar,Jenny Hsieh,Q. Richard Lu +13 more
TL;DR: It is suggested that GPR17 orchestrates the transition between immature and myelinating oligodendrocytes via an ID protein–mediated negative regulation and may serve as a potential therapeutic target for CNS myelin repair.