Jianrong Li

TL;DR: While demyelination was limited in the rostral region of corpus callosum, nearly complete demyELination occurred in the caudal callosUM, beginning at approximately -0.5mm from bregma.

TL;DR: The results reveal that TNFα signaling, rather than peroxynitrite, is essential in LPS-triggered preOL death in an environment containing all major glial cell types and underscore the importance of intercellular communication in determining the mechanism underlying inflammatory pre OL death.

TL;DR: The data indicate that caspase-8 is required for TRAIL-induced apoptosis and suggest that cospase-10 may play a minor role, if any, in TRAil-induced euthanasia, while reverse transcription-PCR and sequence analyses have revealed that these caspases-8-deficient Jurkat cell express wild-type casp enzyme-10.

TL;DR: It is reported here that microglia activated through Toll-like receptors (TLRs) undergo RIP1/RIP3-dependent programmed necrosis (necroptosis) when exposed to the pan caspase inhibitor zVAD-fmk and suggests that TLR signaling and programmed cell death pathways are closely linked inmicroglia, which could contribute to neuropathology and neuroinflammation when dysregulated.

TL;DR: This work identifies stage-specific co-regulators Kaiso and Sox10 that sequentially interact with Tcf7l2 to coordinate the switch at the transitions of differentiation initiation and maturation during oligodendrocyte development, and point to a previously unrecognized role of Tcf8l2 in control of cholesterol biosynthesis for CNS myelinogenesis.