Y
Ying Chen
Researcher at Xiamen University
Publications - 23
Citations - 4114
Ying Chen is an academic researcher from Xiamen University. The author has contributed to research in topics: Oligodendrocyte & OLIG2. The author has an hindex of 18, co-authored 22 publications receiving 3687 citations. Previous affiliations of Ying Chen include University of Texas Southwestern Medical Center.
Papers
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Journal ArticleDOI
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction
Feng Ye,Feng Ye,Ying Chen,ThaoNguyen Hoang,Rusty L. Montgomery,Xian Hui Zhao,Hong Bu,Tom Hu,Makoto Mark Taketo,Johan H. van Es,Hans Clevers,Jenny Hsieh,Rhonda Bassel-Duby,Eric N. Olson,Q. Richard Lu,Q. Richard Lu,Q. Richard Lu +16 more
TL;DR: Crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation.
Journal ArticleDOI
Reelin, lipoprotein receptors and synaptic plasticity
Joachim Herz,Ying Chen +1 more
TL;DR: The molecular mechanisms through which APOE, cholesterol, reelin and APOE receptors control synaptic functions that are essential for cognition, learning, memory, behaviour and neuronal survival are reviewed.
Journal ArticleDOI
MicroRNA-Mediated Control of Oligodendrocyte Differentiation
Xianghui Zhao,Xuelian He,Xuelian He,Xiaolei Han,Yang Yu,Feng Ye,Ying Chen,ThaoNguyen Hoang,Xiaomei Xu,Qing Sheng Mi,Mei Xin,Fan Wang,Bruce Appel,Q. Richard Lu +13 more
TL;DR: It is illustrated that miRNAs are important regulators of oligodendrocyte differentiation, providing new targets for myelin repair by selectively deleting a miRNA-processing enzyme in oligodendedrocytes of spinal cord mice lacking Dicer1.
Journal ArticleDOI
Isolation and culture of rat and mouse oligodendrocyte precursor cells
Ying Chen,Veerakumar Balasubramaniyan,Jie Peng,Edward C. Hurlock,Michelle D. Tallquist,Jianrong Li,Q. Richard Lu +6 more
TL;DR: Simple and efficient methods for the preparation and in vitro maintenance of enriched OPCs from rats and mice are described.
Journal ArticleDOI
Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation
Yang Yu,Yang Yu,Ying Chen,Bong-Woo Kim,Bong-Woo Kim,Haibo Wang,Chuntao Zhao,Xuelian He,Xuelian He,Lei Liu,Lei Liu,Wei Liu,Wei Liu,Lai Man N. Wu,Meng Mao,Jonah R. Chan,Jiang Wu,Q. Richard Lu +17 more
TL;DR: Regulation of the functional specificity and activity of a Smarca4/Brg1-dependent chromatin-remodeling complex by Olig2, coupled with transcriptionally linked chromatin modifications, is critical to precisely initiate and establish the transcriptional program that promotes oligodendrocyte differentiation and subsequent myelination of the CNS.