P
Paul A. Rosenberg
Researcher at Johns Hopkins University School of Medicine
Publications - 249
Citations - 19965
Paul A. Rosenberg is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Excitotoxicity. The author has an hindex of 69, co-authored 225 publications receiving 18397 citations. Previous affiliations of Paul A. Rosenberg include University of Pittsburgh & New York University.
Papers
More filters
Journal ArticleDOI
Excitatory amino acids as a final common pathway for neurologic disorders.
TL;DR: In many neurologic disorders, injury to neurons may be caused at least in part by overstimulation of receptors for excitatory amino acids, including glutamate and aspartate.
Journal ArticleDOI
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
Seija Lehnardt,Leon J. Massillon,Pamela L. Follett,Frances E. Jensen,Rajiv R. Ratan,Paul A. Rosenberg,Joseph J. Volpe,Timothy Vartanian +7 more
TL;DR: A mechanistic link among innate immunity, TLRs, and neurodegeneration is demonstrated and microglia is identified as the major lipopolysaccharide-responsive cell in the CNS.
Journal ArticleDOI
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.
Rachid Skouta,Scott J. Dixon,Jianlin Wang,Denise E. Dunn,Marina Orman,Kenichi Shimada,Paul A. Rosenberg,Donald C. Lo,Joel M. Weinberg,Andreas Linkermann,Brent R. Stockwell +10 more
TL;DR: A mechanistic model to explain the activity of Fer-1 was developed, which guided the development of ferrostatins with improved properties, and that lipid peroxidation mediates diverse disease phenotypes are suggested.
Journal ArticleDOI
The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS
Seija Lehnardt,Christian Lachance,Silvia Patrizi,Sharon Lefebvre,Pamela L. Follett,Frances E. Jensen,Paul A. Rosenberg,Joseph J. Volpe,Timothy Vartanian +8 more
TL;DR: The data provide a general mechanistic link between (1) lipopolysaccharide and similar microbial molecular motifs and (2) injury to oligodendrocytes and myelin as occurs in periventricular leukomalacia and multiple sclerosis.
Journal ArticleDOI
Maturation-Dependent Vulnerability of Oligodendrocytes to Oxidative Stress-Induced Death Caused by Glutathione Depletion
TL;DR: It is reported here that OLs demonstrate maturation-dependent differences in survival when subjected to free radical-mediated injury induced by glutathione depletion, and that oligodendroglial maturation is associated with decreased susceptibility to oxidative stress.