J
Jianxin Yang
Researcher at Second Military Medical University
Publications - 11
Citations - 77
Jianxin Yang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Chemistry & Internal medicine. The author has an hindex of 3, co-authored 6 publications receiving 21 citations.
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Journal ArticleDOI
GPR39 protects against corticosterone-induced neuronal injury in hippocampal cells through the CREB-BDNF signaling pathway
Fengfeng Mo,Yuxiao Tang,Peng Du,Zhilei Shen,Jianxin Yang,Mengyu Cai,Yinyin Zhang,Hongxia Li,Hui Shen +8 more
TL;DR: GPR39 may play a neuroprotective role in CORT-induced cell injury via the improvement of CREB-BDNF expression, by inhibiting pro-apoptotic proteins and by upregulating anti-apopotic proteins.
Journal ArticleDOI
Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.
Yuxiao Tang,Dongyao Wang,Xiaowen Niu,Huiwen Wu,Jianxin Yang,Yinyin Zhang,Shangjin Song,Diya Lv,Yifeng Chai,Hongtao Lu,Hui Shen,Chen Ling,Chen Ling,Min Li,Min Li +14 more
TL;DR: Results elucidate an oxidative-stress-independent, TRIP12/YY1/HNF4α/miR-122/CCL2 pathway of chronic mild HIO inducing hepatic inflammation, implying that effective measures in addition to antioxidants are needed for individuals at the risk of chronic Mild HIO.
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SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes.
Hongxia Li,Dongyao Wang,Huiwen Wu,Hui Shen,Diya Lv,Yinyin Zhang,Hongtao Lu,Jianxin Yang,Yuxiao Tang,Min Li,Min Li +10 more
TL;DR: It is elucidate that SLC46A1 regulates iron metabolism in the liver through a folate-independent manner of importing heme and folate, and gives a new clue to link heme or iron overload with folate deficiency diseases.
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Rapid responses of adipocytes to iron overload increase serum TG level by decreasing adiponectin.
Yuxiao Tang,Dongyao Wang,Dongyao Wang,Hongwei Zhang,Yinyin Zhang,Jie Wang,Ruirui Qi,Jianxin Yang,Hui Shen,Yan Xu,Min Li,Min Li +11 more
TL;DR: In this article, an intraperitoneal injection of 100 mg/kg/day dextran-iron for 5 days, the epididymis adipose showed a remarkable increase in iron.
Journal ArticleDOI
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival
Zhengtai Chen,Hongqiang Wu,Jianxin Yang,Baolong Li,Jian Ding,Sheng Cheng,Nageeb Bsoul,Chenxi Zhang,Jiaorong Li,Haixiao Liu,Damu Lin,Weiyang Gao +11 more
TL;DR: Wang et al. as mentioned in this paper investigated the mechanism of mitophagy induced by Melatonin and its effect on the survival of skin flaps, and showed that Melatonin could activate mitophag, ameliorate oxidative stress and alleviate apoptosis in Tert-Butyl hydroperoxide solution (TBHP)-stimulated human umbilical vein endothelial cells in vitro.