Y
Yinyin Zhang
Researcher at Second Military Medical University
Publications - 6
Citations - 61
Yinyin Zhang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: CREB & Chemistry. The author has an hindex of 3, co-authored 6 publications receiving 21 citations.
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Journal ArticleDOI
GPR39 protects against corticosterone-induced neuronal injury in hippocampal cells through the CREB-BDNF signaling pathway
Fengfeng Mo,Yuxiao Tang,Peng Du,Zhilei Shen,Jianxin Yang,Mengyu Cai,Yinyin Zhang,Hongxia Li,Hui Shen +8 more
TL;DR: GPR39 may play a neuroprotective role in CORT-induced cell injury via the improvement of CREB-BDNF expression, by inhibiting pro-apoptotic proteins and by upregulating anti-apopotic proteins.
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Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.
Yuxiao Tang,Dongyao Wang,Xiaowen Niu,Huiwen Wu,Jianxin Yang,Yinyin Zhang,Shangjin Song,Diya Lv,Yifeng Chai,Hongtao Lu,Hui Shen,Chen Ling,Chen Ling,Min Li,Min Li +14 more
TL;DR: Results elucidate an oxidative-stress-independent, TRIP12/YY1/HNF4α/miR-122/CCL2 pathway of chronic mild HIO inducing hepatic inflammation, implying that effective measures in addition to antioxidants are needed for individuals at the risk of chronic Mild HIO.
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SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes.
Hongxia Li,Dongyao Wang,Huiwen Wu,Hui Shen,Diya Lv,Yinyin Zhang,Hongtao Lu,Jianxin Yang,Yuxiao Tang,Min Li,Min Li +10 more
TL;DR: It is elucidate that SLC46A1 regulates iron metabolism in the liver through a folate-independent manner of importing heme and folate, and gives a new clue to link heme or iron overload with folate deficiency diseases.
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Rapid responses of adipocytes to iron overload increase serum TG level by decreasing adiponectin.
Yuxiao Tang,Dongyao Wang,Dongyao Wang,Hongwei Zhang,Yinyin Zhang,Jie Wang,Ruirui Qi,Jianxin Yang,Hui Shen,Yan Xu,Min Li,Min Li +11 more
TL;DR: In this article, an intraperitoneal injection of 100 mg/kg/day dextran-iron for 5 days, the epididymis adipose showed a remarkable increase in iron.
Journal ArticleDOI
miR-182 mediated the inhibitory effects of NF-κB on the GPR39/CREB/BDNF pathway in the hippocampus of mice with depressive-like behaviors.
X.Muxammadieva X.Abdumajitov,Yuxiao Tang,Nicolás Arata,Jianxin Yang,Chuyang Ye,Xin Xu,Mengyu Cai,Yinyin Zhang,Hongtao Lu,Fengfeng Mo,Hongxia Li,Hui Shen +11 more
TL;DR: In this paper, the activation of NF-κB and inhibition of GPR39 were connected by bioinformatic analysis and experimentally validated in hippocampus cells by knock-in and knock-down techniques.