J
Jiao Jiao Lin
Researcher at Columbia University
Publications - 7
Citations - 1511
Jiao Jiao Lin is an academic researcher from Columbia University. The author has contributed to research in topics: Cellular differentiation & Subtraction hybridization. The author has an hindex of 7, co-authored 7 publications receiving 1488 citations.
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Journal Article
Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression
TL;DR: Results confirm that mda-7 has antiproliferative properties in human melanoma cells and in this context may contribute to terminal cell differentiation.
Journal ArticleDOI
The melanoma differentiation associated gene mda-7 suppresses cancer cell growth
Hongping Jiang,Zao-Zhong Su,Jiao Jiao Lin,Neil I. Goldstein,Charles S. H. Young,Paul B. Fisher +5 more
TL;DR: The ability of mda-7 to suppress growth in cancer cells not expressing or containing defects in both the retinoblastoma (RB) and p53 genes indicates a lack of involvement of these critical tumor suppressor elements in mediating mDA-7-induced growth inhibition.
Journal ArticleDOI
The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice
Zao-Zhong Su,Malavi T. Madireddi,Jiao Jiao Lin,Charles S. H. Young,Shinichi Kitada,John C. Reed,Neil I. Goldstein,Paul B. Fisher +7 more
TL;DR: The data suggest that mda-7 induces its selective anticancer properties in human breast carcinoma cells by promoting apoptosis that occurs independent of p53 status, a new class of cancer suppressor genes that could prove useful for the targeted therapy of human cancer.
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Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.
Eric Y Huang,Malavi T. Madireddi,Malavi T. Madireddi,Rahul V. Gopalkrishnan,Magdalena Leszczyniecka,Zao-Zhong Su,Irina V. Lebedeva,Dong-Chul Kang,Hongping Jiang,Jiao Jiao Lin,Deborah Alexandre,Yinming Chen,Nicollaq Vozhilla,Mei Xin Mei,Keith A Christiansen,Frank Sivo,Neil I. Goldstein,Abner Mhashilkar,Sunil Chada,Eliezer Huberman,Sidney Pestka,Paul B. Fisher +21 more
TL;DR: Mda-7 represents a differentiation, growth and apoptosis associated gene with potential utility for the gene-based therapy of diverse human cancers.
Journal ArticleDOI
Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene
TL;DR: It is established that induction of terminal differentiation in human melanoma cells, using the combination of a type I interferon (IFN-beta) + MEZ, can elicit signaling pathways and gene expression changes also regulated by type II immuneinterferon.