J
J. M. Millholland
Publications - 5
Citations - 1743
J. M. Millholland is an academic researcher. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 2, co-authored 2 publications receiving 1676 citations.
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Journal ArticleDOI
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.
Qing Wang,Mark E. Curran,Igor Splawski,Timothy C. Burn,J. M. Millholland,T. J. VanRaay,Jiaxiang Shen,Katherine W. Timothy,Vincent Gm,Vincent Gm,T. De Jager,Peter J. Schwartz,J.A. Towbin,Arthur J. Moss,Donald L. Atkinson,Gregory M. Landes,Timothy D. Connors,M T Keating +17 more
TL;DR: In this article, positional cloning was used to establish KVLQT1 as the chromosome 11-linked LQT 1 gene responsible for the most common inherited cardiac arrhythmia.
Journal ArticleDOI
Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.
Timothy C. Burn,Timothy D. Connors,T J Van Raay,William R. Dackowski,J. M. Millholland,K W Klinger,Gregory M. Landes +6 more
TL;DR: A transcriptional map for the 700 kb of DNA surrounding the PKD1 and TSC2 genes is presented and two newly identified genes represent human homologs for rat and murine genes identified previously.
Journal ArticleDOI
A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear Cell Renal Cell Carcinoma.
Phillip M. Rappold,Lynda Vuong,Josef Leibold,Nicholas H. Chakiryan,Michael P. Curry,Fengshen Kuo,Erich Y. Sabio,Hui Jiang,Briana G. Nixon,Ming Li,Anders Berglund,Andrew W. Silagy,Ankur Mascareno,Mahdi Golkaram,Mahtab Marker,Albert Reising,Alexander Savchenko,J. M. Millholland,Ying-Bei Chen,Paul Russo,Jonathan A. Coleman,Ed Reznik,Brandon J. Manley,Irina Ostrovnaya,Vladimir Makarov,Renzo G. DiNatale,Kyle A. Blum,Xiaoxiao Ma,Diego Chowell,Ming O. Li,David B. Solit,Scott W. Lowe,Timothy A. Chan,Robert J. Motzer,Martin H. Voss,A. Ari Hakimi +35 more
TL;DR: Targeting immunosuppressive myeloid inflammation with an adenosine A2A receptor antagonist in a novel, immunocompetent, Tp53-inactivated mouse model significantly reduces metastatic development and provides a potential biomarker-based framework for the design of future immuno-oncology trials in ccRCC.
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P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion
Érica Martins Ferreira Gotardo,Lidiane de Souza Torres,Lucas Fernando Sérgio Gushiken,Pamela L. Brito,Flavia C. Leonardo,Sergei Agoulnik,Jiri Kovarik,Andreas Bruederle,J. M. Millholland,Alessandra Vitaliti,Irmgard Förster,Fernando Ferreira Costa,Nicola Conran +12 more
TL;DR: In this paper , the authors evaluated the combined effects of P-selectin blockage, together with IL-1β and/or IL-18 neutralization, on WBC recruitment during tumor necrosis factor-α (TNF)-induced VO processes in SCD mice.
Journal ArticleDOI
Targeting the IL-1β pathway for cancer immunotherapy remodels the tumor microenvironment and enhances antitumor immune responses.
Rohan Diwanji,Neil A. O'Brien,Jiyoung Elizabeth Choi,Beverly Nguyen,Tyler Laszewski,Angelo Grauel,Zheng Yan,Xin Xu,Jincheng Wu,David A. Ruddy,Michelle Piquet,Marc Pelletier,Alexander Savchenko,LaSalette Charette,Vanessa Rodrik-Outmezguine,Jason Baum,J. M. Millholland,C. Wong,Glenn Dranoff,Iulian Pruteanu-Malinici,Viviana Cremasco,Pushpa Jayaraman +21 more
TL;DR: In this article , the effects of IL-1β blockade induced by the monoclonal antibodies canakinumab and gevokizumab were evaluated alone or in combination with docetaxel, anti-PD-1 and anti-VEGFβ treatment in syngeneic and humanized mouse models of cancers of different origin.